ArticleScientific reports2021
Using approach latency and anticipatory behaviour to assess whether voluntary playpen access is rewarding to laboratory mice.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Age-dependent vulnerability to spatial memory interference in APP/PS1 mice.Frontiers in aging neuroscience · 2026Article
- The effects of handling on mouse behavior: cupped hands versus familiar or novel huts or tunnels.PloS one · 2025Article
- Effects of access to a well-resourced environment on dairy calf cognition and affective state.PloS one · 2025Article
- Anticipatory Behaviour During the Approach to Feeding Times as a Measure of Horse Welfare.Animals : an open access journal from MDPI · 2024Article
- Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare.Scientific reports · 2024Article
- Lockbox enrichment facilitates manipulative and cognitive activities for mice.Open research Europe · 2024Article
- Benchmarking Enrichment Efforts in the US & Canada Across Species and Enrichment Categories.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023Article
- Multimodal Communication in the Human-Cat Relationship: A Pilot Study.Animals : an open access journal from MDPI · 2023Article
- Long-Term Spatial Restriction Generates Deferred Limited Space Use in a Zoo-Housed Chimpanzee Group.Animals : an open access journal from MDPI · 2022Article
- Environmental Enrichment for Rats and Mice Housed in Laboratories: A Metareview.Animals : an open access journal from MDPI · 2022Review
- Temporal dynamics of affect in the brain: Evidence from human imaging and animal models.Neuroscience and biobehavioral reviews · 2022Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory mice are typically housed in "shoebox" cages that limit the expression of natural behaviours. Temporary access to more complex environments (playpens) may improve their welfare. We aimed to assess if access to playpens is rewarding for conventionally-housed mice and to document mouse behaviour during playpen access. Female C57BL/6J, BALB/cJ, and DBA/2J mice were provided temporary access to a large enriched playpen three times per week; control mice remained in their home cages. We measured latency to enter playpens and anticipatory behaviour to determine if access was rewarding, and recorded mouse behaviour during playpen sessions. Over time, playpen mice entered the playpen more quickly; latency declined from 168 ± 22 to 13 ± 2 s over the 14-d trial. As expected, playpen mice showed an increase in anticipatory behaviour before playpen access (mean ± SE = 19.7 ± 2.6 behavioural transitions), while control mice showed no change in anticipatory behaviour relative to baseline values (2.4 ± 1.6 transitions). Mice in the playpen performed more ambulatory behaviours than control mice who remained in home cages (21.5 ± 0.7 vs 6.9 ± 1.1 observations of 25 total observations). We conclude that conventionally-housed mice find voluntary playpen access rewarding, and suggest this as a useful option for providing laboratory mice with access to more complex environments.
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