Evidence map›Paper›PMID 34548575›Full record

ArticleScientific reports2021

Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicit vasoconstriction of the murine ophthalmic artery.

Jiong Hu, Marco Sisignano, Roman Brecht, Natarajan Perumal, Carlo Angioni, Iris-Sofia Bibli, Beate Fisslthaler, Hartmut Kleinert, Norbert Pfeiffer, Ingrid Fleming and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Indirubin-3'-oxime as a dual-action agent: mitigating heat-induced male infertility inJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jiong HuInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
Marco SisignanoPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Goethe-University, Frankfurt, Germany.
Roman BrechtDepartment of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
Natarajan PerumalDepartment of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.ORCID http://orcid.org/0000-0002-2612-5907
Carlo AngioniPharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Goethe-University, Frankfurt, Germany.
Iris-Sofia BibliInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
Beate FisslthalerInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
Hartmut KleinertDepartment of Pharmacology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.
Norbert PfeifferDepartment of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
Ingrid FlemingInstitute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany.
Caroline ManicamDepartment of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. caroline.manicam@unimedizin-mainz.de.ORCID http://orcid.org/0000-0001-5891-1155
Goethe University Frankfurt · DEJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytochrome P450 (CYP) signalling pathway has been shown to play a vital role in the vasoreactivity of wild type mouse ophthalmic artery. In this study, we determined the expression, vascular responses and potential mechanisms of the CYP-derived arachidonic acid metabolites. The expression of murine CYP (Cyp2c44) and soluble epoxide hydrolase (sEH) in the wild type ophthalmic artery was determined with immunofluorescence, which showed predominant expression of Cyp2c44 in the vascular smooth muscle cells (VSMC), while sEH was found mainly in the endothelium of the wild type ophthalmic artery. Artery of Cyp2c44

Indexed as

AnimalsCytochrome P450 Family 2Epoxide HydrolasesFatty Acids, MonounsaturatedMiceOphthalmic ArteryVasoconstrictionCyp2c23 protein, mouseCytochrome P450 Family 2eicosenoic acidEphx2 protein, mouseEpoxide HydrolasesFatty Acids, Monounsaturated

Identifiers

PMID34548575
PMCPMC8455677
OpenAlexW3199977614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.