Evidence map›Paper›PMID 34548574›Full record

ArticleScientific reports2021

Deep learning-based prediction of early cerebrovascular events after transcatheter aortic valve replacement.

Taishi Okuno, Pavel Overtchouk, Masahiko Asami, Daijiro Tomii, Stefan Stortecky, Fabien Praz, Jonas Lanz, George C M Siontis, Christoph Gräni, Stephan Windecker and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Observational
  3. Redefining Stroke Care with Artificial Intelligence: Recent Advances.Current neurology and neuroscience reports · 2026
    Review
  4. Clinical Applications of Artificial Intelligence in Structural Heart Disease.Journal of the Society for Cardiovascular Angiography & Interventions · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Harnessing Artificial Intelligence for Innovation in Interventional Cardiovascular Care.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Review
  9. Cerebrovascular events after transcatheter aortic valve implantation.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2024
    Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Taishi Okuno *Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Pavel Overtchouk *Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. pavel@alviss.ai.
Masahiko AsamiDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Daijiro TomiiDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Stefan StorteckyDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Fabien PrazDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jonas LanzDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
George C M SiontisDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christoph GräniDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Stephan WindeckerDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Thomas PilgrimDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebrovascular events (CVE) are among the most feared complications of transcatheter aortic valve replacement (TAVR). CVE appear difficult to predict due to their multifactorial origin incompletely explained by clinical predictors. We aimed to build a deep learning-based predictive tool for TAVR-related CVE. Integrated clinical and imaging characteristics from consecutive patients enrolled into a prospective TAVR registry were analysed. CVE comprised any strokes and transient ischemic attacks. Predictive variables were selected by recursive feature reduction to train an autoencoder predictive model. Area under the curve (AUC) represented the model's performance to predict 30-day CVE. Among 2279 patients included between 2007 and 2019, both clinical and imaging data were available in 1492 patients. Median age was 83 years and STS score was 4.6%. Acute (< 24 h) and subacute (day 2-30) CVE occurred in 19 (1.3%) and 36 (2.4%) patients, respectively. The occurrence of CVE was associated with an increased risk of death (HR [95% CI] 2.62 [1.82-3.78]). The constructed predictive model uses less than 107 clinical and imaging variables and has an AUC of 0.79 (0.65-0.93). TAVR-related CVE can be predicted using a deep learning-based predictive algorithm. The model is implemented online for broad usage.

Indexed as

Deep LearningAgedAged, 80 and overFemaleHumansIncidenceMaleProspective StudiesRisk FactorsStrokeTomography, X-Ray ComputedTranscatheter Aortic Valve Replacement

Identifiers

PMID34548574
PMCPMC8455675

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.