ArticleScientific reports2021
Biomarkers of cellular aging during a controlled human malaria infection.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- CumulativeFrontiers in cellular and infection microbiology · 2026Article
- Naturally acquired malaria is associated with shorter leukocyte relative telomere length and increased hTERT expression in an endemic nigerian population.Frontiers in cellular and infection microbiology · 2026Article
- Review
- The impacts of chronic infections on shaping cellular senescence.Immunity & ageing : I & A · 2025Review
- Global research landscape of telomere biology in infectious diseases: mechanistic links between host-pathogen interactions and immune ageing.Frontiers in aging · 2025Review
- Malaria endemicity linked to shorter telomeres in leukocytes.Trends in parasitology · 2024Article
- The Impact of HIV and Parasite Single Infection and Coinfection on Telomere Length: A Systematic Review.Current issues in molecular biology · 2024Review
- Telomere Length in a South African Population Co-Infected with HIV and Helminths.Current issues in molecular biology · 2024Article
- Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans.American journal of human genetics · 2024Article
- Systems biology of malaria explored with nonhuman primates.Malaria journal · 2022Review
- Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite.Current topics in medicinal chemistry · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.