Evidence map›Paper›PMID 34548499›Full record

ArticleNPJ schizophrenia2021

No association between cortical dopamine D2 receptor availability and cognition in antipsychotic-naive first-episode psychosis.

Maria Lee, Helena Fatouros-Bergman, Pontus Plavén-Sigray, Pauliina Ikonen Victorsson, Carl M Sellgren, Sophie Erhardt, Lena Flyckt, Lars Farde, Simon Cervenka

Open access · goldAbstract read
In one paragraph

Article in NPJ schizophrenia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Maria LeeCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden. maria.lee@ki.se.ORCID http://orcid.org/0000-0003-4080-4030
Helena Fatouros-BergmanCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Pontus Plavén-SigrayCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Pauliina Ikonen VictorssonCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Carl M SellgrenDepartment of Physiology and Pharmacology, Karolinska Institutet, SE- 171 77, Stockholm, Sweden.
Sophie ErhardtDepartment of Physiology and Pharmacology, Karolinska Institutet, SE- 171 77, Stockholm, Sweden.
Lena FlycktCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
Lars FardeCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-1297-0816
Simon CervenkaCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-8103-6977
Karolinska Institutet · SECopenhagen University Hospital · DKUppsala University · SE

Funding

Vetenskapsrådet (Swedish Research Council) 09114Vetenskapsrådet (Swedish Research Council) 2017-00875Vetenskapsrådet (Swedish Research Council) 523-2014-3467
6 · The paper itself

Abstract

Cognitive impairment is an important predictor of disability in schizophrenia. Dopamine neurotransmission in cortical brain regions has been suggested to be of importance for higher-order cognitive processes. The aim of this study was to examine the relationship between extrastriatal dopamine D2-R availability and cognitive function, using positron emission tomography and the high-affinity D2-R radioligand [

Identifiers

PMID34548499
PMCPMC8455597
OpenAlexW3201627177

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.