Evidence map›Paper›PMID 34548404›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The

Caitlin E Monaghan, Scott I Adamson, Mridu Kapur, Jeffrey H Chuang, Susan L Ackerman

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026
    Review
  3. Enzymology of the metazoan tRNA ligase complex: a lifetime in cycles.Cellular and molecular life sciences : CMLS · 2026
    Review
  4. Review
  5. Review
  6. Emerging roles of transfer RNA fragments in the CNS.Brain : a journal of neurology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Pathogenic mechanism and therapeutic intervention of impaired NProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. The life and times of a tRNA.RNA (New York, N.Y.) · 2023
    Review
  16. Article
  17. Captured: the elusive eukaryotic tRNA splicing enzyme.Nature structural & molecular biology · 2023
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Caitlin E MonaghanDepartment of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-7055-3610
Scott I AdamsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.
Mridu KapurDepartment of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093.
Jeffrey H ChuangThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06030.
Susan L AckermanDepartment of Cellular and Molecular Medicine, Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, CA 92093; sackerman@ucsd.edu.ORCID 0000-0002-6740-593X
University of California San Diego · USInstitute for Systems Biology · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Function of the RNA kinase CLP1 in Neuronal SurvivalR21NS116611 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACKERMAN, SUSAN L · 2020 to 2020
$433k
Howard Hughes Medical InstituteNIH HHS S10 OD026929NINDS NIH HHS P30 NS047101NINDS NIH HHS R21 NS116611
6 · The paper itself

Abstract

Homozygous mutation of the RNA kinase

Indexed as

PolyadenylationRNA Processing, Post-TranscriptionalAnimalsCerebellar DiseasesDisease Models, AnimalFemaleGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutMutationNeurodegenerative DiseasesRNA-Binding ProteinsRNA, MessengerRNA PrecursorsHexim1 protein, mouseRNA-Binding ProteinsRNA, MessengerRNA PrecursorsRNA, TransferTranscription Factorsalternative polyadenylationcleavage factor IIdeep cerebellar nucleimotor neuron degenerationtRNA splicing

Identifiers

PMID34548404
PMCPMC8488643
OpenAlexW3200401423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.