Evidence map›Paper›PMID 34548394›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe.

Marta T Borowska, Christoph Drees, Alexander E Yarawsky, Mayuri Viswanathan, Sean M Ryan, Jeffrey J Bunker, Andrew B Herr, Albert Bendelac, Erin J Adams

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marta T BorowskaDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8223-530X
Christoph DreesDepartment of Pathology, University of Chicago, Chicago, IL 60637.
Alexander E YarawskyDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229.ORCID 0000-0002-5973-5058
Mayuri ViswanathanCommittee on Immunology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8559-042X
Sean M RyanCommittee on Immunology, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-8347-3425
Jeffrey J BunkerDepartment of Pathology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-9351-7003
Andrew B HerrDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229.ORCID 0000-0002-3598-3399
Albert BendelacDepartment of Pathology, University of Chicago, Chicago, IL 60637; ejadams@uchicago.edu abendela@bsd.uchicago.edu.ORCID 0000-0003-1859-206X
Erin J AdamsDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637; ejadams@uchicago.edu abendela@bsd.uchicago.edu.ORCID 0000-0002-6271-8574
University of Chicago · USCincinnati Children's Hospital Medical Center · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Transcriptional Regulation of Innate-Like T CellsR01AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI ESTERHAZY, DARIA · 1996 to 2025
$7.6M
Transcriptional Regulation of Innate-Like T CellsR37AI038339 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2017 to 2023
$3.4M
STUDIES OF METAL-DEPENDENT INTERCELLULAR ADHESION IN STAPHYLOCOCCAL BIOFILMSR01GM094363 · NIGMS · UNIVERSITY OF CINCINNATI · PI HERR, ANDREW B · 2011 to 2021
$2.5M
Development of Intestinal Polyreactive IgA B CellsR01AI144094 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2019 to 2023
$2.5M
Specificity of Intestinal Immunoglobulin AU01AI125250 · NIAID · UNIVERSITY OF CHICAGO · PI BENDELAC, ALBERT S. · 2016 to 2020
$2.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
Specificity of Intestinal Immunoglobulin AF30AI124476 · NIAID · UNIVERSITY OF CHICAGO · PI BUNKER, JEFFREY J · 2016 to 2019
$197k
NIAID NIH HHS F30 AI124476NIAID NIH HHS R01 AI038339NIAID NIH HHS R01 AI144094NIAID NIH HHS R37 AI038339NIAID NIH HHS T32 AI007090NIAID NIH HHS U01 AI125250NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM094363NIGMS NIH HHS T32 GM007281NIH HHS S10 OD018483NIH HHS S10 OD021527
6 · The paper itself

Abstract

Microorganisms have coevolved diverse mechanisms to impair host defenses. A major one, superantigens, can result in devastating effects on the immune system. While all known superantigens induce vast immune cell proliferation and come from opportunistic pathogens, recently, proteins with similar broad specificity to antibody variable (V) domain families were identified in a commensal microbiota. These proteins, identified in the human commensal

Indexed as

AnimalsAntibodies, MonoclonalBinding SitesB-LymphocytesEubacterialesHumansImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionMiceMice, Inbred C57BLReceptors, Antigen, B-CellSuperantigensAntibodies, MonoclonalImmunoglobulin Heavy ChainsImmunoglobulin Variable RegionReceptors, Antigen, B-CellSuperantigensantibodycommensal microbeimmunoglobulin-binding proteinRuminococcus gnavussuperantigen

Identifiers

PMID34548394
PMCPMC8488583
OpenAlexW3200422862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.