Evidence map›Paper›PMID 34548381›Full record

ArticleLife science alliance2021

Elevated glycolysis imparts functional ability to CD8

Akm Nur-Ur Rahman, Jun Liu, Shariq Mujib, Segen Kidane, Arman Ali, Steven Szep, Carrie Han, Phil Bonner, Michael Parsons, Erika Benko and 3 more

Open access · goldAbstract read
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Immuno-cell metabolic changes in HIV-1 infection.Infectious diseases & immunity · 2025
    Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Frontiers in immunology · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Akm Nur-Ur RahmanDeparment of Medicine, University of Toronto, Toronto, Canada.
Jun LiuDeparment of Medicine, University of Toronto, Toronto, Canada.
Shariq MujibInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Segen KidaneInstitute of Medical Sciences, University of Toronto, Toronto, Canada.
Arman AliDeparment of Medicine, University of Toronto, Toronto, Canada.
Steven SzepDeparment of Medicine, University of Toronto, Toronto, Canada.
Carrie HanDeparment of Medicine, University of Toronto, Toronto, Canada.
Phil BonnerDeparment of Medicine, University of Toronto, Toronto, Canada.
Michael ParsonsFlow Cytometry Facility, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.
Erika BenkoMaple Leaf Medical Clinic, Toronto, Canada.
Colin KovacsMaple Leaf Medical Clinic, Toronto, Canada.
Feng Yun YueDeparment of Medicine, University of Toronto, Toronto, Canada.
Mario OstrowskiDeparment of Medicine, University of Toronto, Toronto, Canada mario.ostrowski@gmail.com.
University of Toronto · CAMaple Leaf Medical Clinic · CAMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms inducing exhaustion of HIV-specific CD8

Indexed as

CD8-Positive T-LymphocytesGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)GlycolysisHIV-1HIV InfectionsHumansLymphocyte ActivationOxidative PhosphorylationOxygen ConsumptionTOR Serine-Threonine KinasesGAPDH protein, humanGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)TOR Serine-Threonine Kinases

Identifiers

PMID34548381
PMCPMC8473722
OpenAlexW3200587016

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.