ArticleGut2022
Timing of endoscopy for acute upper gastrointestinal bleeding: a territory-wide cohort study.
Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- Advances in standardized diagnosis and management of pediatric gastrointestinal bleeding.World journal of pediatrics : WJP · 2025Pooled it
- Quality indicators for upper GI endoscopy.Gastrointestinal endoscopy · 2025Guideline
- Does Early Endoscopy Affect the Clinical Outcomes of Patients with Acute Nonvariceal Upper Gastrointestinal Bleeding? A Systematic Review and Meta-Analysis.Gut and liver · 2023Pooled it
- Endoscopic Treatment of Upper Gastrointestinal Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Socioeconomic inequalities and dynamic changes in sex differences in lifetime risks of peptic ulcer disease.Biology of sex differences · 2026Article
- Endoscopic variceal ligation versus sclerotherapy in patients with gastric variceal bleed.BMC surgery · 2026Article
- Association of time to red blood cell transfusion on outcomes in patients with gastrointestinal bleeding.Annals of medicine · 2025Article
- Minutes to Save a Life in Acute GI Bleeding: A Systematic Review of Early vs. Delayed Endoscopy.Cureus · 2025Review
- Development of a deep learning model for guiding treatment decisions of acute variceal bleeding in patients with cirrhosis.World journal of gastroenterology · 2025Article
- Impact of Red Pack Cell Transfusion Before or After Endoscopy on Mortality in Patients with Upper Gastrointestinal Bleeding: A Multicenter Cohort Study.Diseases (Basel, Switzerland) · 2025Article
- [Risk Factors for Mortality in Hemodialysis Patients With Gastrointestinal Bleeding].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Amino acid metabolism pathways as key regulators of nitrogen distribution in tobacco: insights from transcriptome and WGCNA analyses.BMC plant biology · 2025Article
- The Long-Term Risk of Metachronous Advanced Adenoma Recurrence After Endoscopic Submucosal Dissection for Colorectal Neoplasia: A Propensity-Score Matched Longitudinal Cohort With 5-Year Follow-Up.United European gastroenterology journal · 2025Article
- Defining and Evaluating the Impact of Bleeding Severity on Time to Endoscopy and Mortality Risk: A Prospective Multicenter Cohort Study.Journal of clinical medicine · 2025Article
- Quality Indicators for Upper GI Endoscopy.The American journal of gastroenterology · 2025Article
- CT-based nomogram predicts esophageal gastric variceal bleeding in noncirrhotic portal hypertension caused by hepatic schistosomiasis.BMC medical informatics and decision making · 2025Article
- Upper gastrointestinal bleeding differences between older and younger adults: should bleeding in non-cirrhotic patients be considered a geriatric syndrome?Therapeutic advances in gastroenterology · 2025Article
- The future of critical care: AI-powered mortality prediction for acute variceal gastrointestinal bleeding and acute non-variceal gastrointestinal bleeding patients.Frontiers in medicine · 2025Article
- Impact of Timing of Endoscopy on Mortality in Non-variceal Upper Gastrointestinal Bleeding: A Retrospective Cohort Study :.Galen medical journal · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWhile it is recommended that patients presenting with acute upper gastrointestinal bleeding (AUGIB) should receive endoscopic intervention within 24 hours, the optimal timing is still uncertain. We aimed to assess whether endoscopy timing postadmission would affect outcomes.
designWe conducted a retrospective, territory-wide, cohort study with healthcare data from all public hospitals in Hong Kong. Adult patients (age ≥18) that presented with AUGIB between 2013 and 2019 and received therapeutic endoscopy within 48 hours (n=6474) were recruited. Patients were classified based on endoscopic timing postadmission: urgent (t≤6), early (6<t≤24) and late (24<t≤48). Baseline characteristics were balanced with inverse probability of treatment weighting. 30-day all-cause mortality, repeated therapeutic endoscopy rate, intensive care unit (ICU) admission rate and other endpoints were compared.
resultsResults showed that urgent timing (n=1008) had worse outcomes compared with early endoscopy (n=3865), with higher 30-day all-cause mortality (p<0.001), repeat endoscopy rates (p<0.001) and ICU admission rates (p<0.001). Late endoscopy (n=1601) was associated with worse outcomes, with higher 30-day mortality (p=0.003), in-hospital mortality (p=0.022) and 30-day transfusion rates (p=0.018).
conclusionCompared with urgent and late endoscopy among patients who have received therapeutic endoscopies, early endoscopy was associated with superior outcomes especially among patients with non-variceal bleeding. This supports the notion that non-variceal AUGIB patients should receive endoscopy within 24 hours, but also emphasises the importance of prior resuscitation and pharmacotherapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.