Evidence map›Paper›PMID 34548302›Full record

ArticleBMJ case reports2021

Pembrolizumab-induced autoimmune haemolytic anemia in a patient with chronic lymphocytic leukaemia successfully treated with ibrutinib.

Nicole K Yun, Taha Alrifai, Ira J Miller, Melissa L Larson

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole K YunDepartment of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA nicole_k_yun@rush.edu.ORCID http://orcid.org/0000-0002-3668-9618
Taha AlrifaiDivision of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, Illinois, USA.
Ira J MillerDepartment of Pathology, Rush University Medical Center, Chicago, Illinois, USA.
Melissa L LarsonDivision of Hematology, Oncology, and Stem Cell Transplant, Rush University Medical Center, Chicago, Illinois, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a unique case of a patient with a long-standing history of indolent chronic lymphocytic leukaemia (CLL) who suddenly developed autoimmune haemolytic anaemia after starting immune checkpoint inhibitor therapy for bladder cancer. He had no clear indication to start CLL-directed treatment based on current clinical practice guidelines; however, targeted treatment of CLL with ibrutinib proved to be effective in treating the haemolytic anaemia.

Indexed as

Anemia, Hemolytic, AutoimmuneLeukemia, Lymphocytic, Chronic, B-CellAdenineAntibodies, Monoclonal, HumanizedHumansMalePiperidinesAdenineAntibodies, Monoclonal, HumanizedibrutinibpembrolizumabPiperidineshaematology (drugs and medicines)haematology (incl blood transfusion)malignant and benign haematology

Identifiers

PMID34548302
PMCPMC8458375

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.