ReviewDiabetes care2021
Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC).
Review in Diabetes care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Association between glycated hemoglobin variability and risk of diabetic kidney disease and diabetic retinopathy in diabetic patients: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Visual impairment among diabetes patients in Ethiopia: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Transient elevation in cellular glucose uptake exacerbates pressure overload-induced cardiac hypertrophy and dysfunction.Epigenetics · 2026Article
- Review
- Interpretable single-cell machine learning identifies PINK1-centred mitophagy as a determinant of metabolic fitness in type 2 diabetes.Acta diabetologica · 2026Article
- From Guidelines to Clinical Practice: Expert Perspectives on Long-Term Management of Obesity.Obesity (Silver Spring, Md.) · 2026Review
- Dynamic Oculomics for Diagnostic Monitoring: Personal Ocular Trends, Risk Stratification and Treatment Response.Diagnostics (Basel, Switzerland) · 2026Review
- Foveal Density and Multi-Domain OCTA Biomarkers May Help Identify Preclinical Diabetic Microvasculopathy in Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2026Article
- Beyond Glucose: Palmitic Acid Influences VEGFA-VEGFR2 Angiogenic Signaling in Müller Glial Cells.International journal of molecular sciences · 2026Article
- Timing of Antidiabetic Medication Initiation and Risk of Cardiovascular Events and Mortality.JAMA network open · 2026Article
- Diabetic Retinopathy Outcomes and Early Worsening of Diabetic Retinopathy in Adolescents and Young Adults With Type 1 Diabetes Following Rapid and Large Glycemic Improvements After Commencing Automated Insulin Delivery.Journal of diabetes science and technology · 2026Article
- Dynamic associations of BMI-metabolic phenotype transitions with incident cardiovascular disease in middle-aged and elderly adults: a longitudinal cohort study.BMC cardiovascular disorders · 2026Article
- Melatonin and Quercetin Co-Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation.Journal of biochemical and molecular toxicology · 2026Article
- DNMT inhibitor ameliorates hyperglycemia and renal inflammation partially via reversing hypermethylation-induced Klotho suppression in diabetic mice.Clinical epigenetics · 2026Article
- Timing of insulin pump initiation among individuals with type 1 diabetes in Ontario, Canada.Diabetes, obesity & metabolism · 2026Article
- Emerging innovations in ophthalmic drug delivery for diabetic retinopathy: a translational perspective.Drug delivery and translational research · 2026Review
- Type 1 diabetes screening: building a clinician-patient partnership for early care of chronic beta cell failure.Diabetologia · 2026Article
- Article
- Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease.Diabetologia · 2026Article
- Heterogeneous Kidney Patterns in Diabetic Patients Following SGLT2 Inhibitor Use.Journal of Korean medical science · 2026Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The Diabetes Control and Complications Trial (DCCT, 1983-1993) showed that intensive therapy (mean HbA
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.