ArticleThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2021
Lung transplantation disparities based on diagnosis for patients bridging to transplant on extracorporeal membrane oxygenation.
Article in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Extracorporeal membrane oxygenation vs cardiopulmonary bypass in lung transplantation: an updated meta-analysis.General thoracic and cardiovascular surgery · 2025Pooled it
- Waitlist outcome differences for pulmonary hypertension patients are worse in the CAS era.JHLT open · 2026Article
- Racial, ethnic, and sex disparities in lung transplant waitlist outcomes before and after composite allocation score implementation.JHLT open · 2026Article
- Extracorporeal membrane oxygenation bridge to transplant in the era of the lung composite allocation score.JHLT open · 2025Article
- Outcomes with venoarterial vs venovenous extracorporeal membrane oxygenation as a bridge to lung transplantation in interstitial lung disease.JHLT open · 2025Article
- Impact of pretransplant extracorporeal membrane oxygen support duration on lung transplant outcomes: United Network for Organ Sharing analysis.JTCVS open · 2025Article
- Health disparities and associated social determinants of health in interstitial lung disease: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Management strategies and outcomes predictors of interstitial lung disease exacerbation admitted to an intensive care setting: A narrative review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Review
- ECMO for bridging lung transplantation.European journal of medical research · 2024Review
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- New OPTN/UNOS data demonstrates higher than previously reported waitlist mortality for lung transplant candidates supported with ECMO.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Extracorporeal Membrane Oxygenation in Acute Respiratory Failure.Pulmonary therapy · 2023Review
- New Aspects of Lung Transplantation: A Narrative Overview Covering Important Aspects of Perioperative Management.Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExtracorporeal membrane oxygenation (ECMO) is increasingly utilized as a bridge to lung transplantation, but ECMO status is not explicitly accounted for in the Lung Allocation Score (LAS). We hypothesized that among waitlist patients on ECMO, patients with pulmonary arterial hypertension (PAH) would have lower transplantation rates.
methodsUsing United Network for Organ Sharing data, we conducted a retrospective cohort study of patients who were ≥12 years old, active on the lung transplant waitlist, and required ECMO support from June 1, 2015 through June 12, 2020. Multivariable competing risk analysis was used to examine waitlist outcomes.
results1064 waitlist subjects required ECMO support; 40 (3.8%) had obstructive lung disease (OLD), 97 (9.1%) had PAH,138 (13.0%) had cystic fibrosis (CF), and 789 (74.1%) had interstitial lung disease (ILD). Ultimately, 671 (63.1%) underwent transplant, while 334 (31.4%) died or were delisted. The transplant rate per person-years on the waitlist on ECMO was 15.41 for OLD, 6.05 for PAH, 15.66 for CF, and 15.62 for ILD. Compared to PAH patients, OLD, CF, and ILD patients were 78%, 69%, and 62% more likely to undergo transplant throughout the study period, respectively (adjusted SHRs 1.78 p = 0.007, 1.69 p = 0.002, and 1.62 p = 0.001). The median LAS at waitlist removal for transplantation, death, or delisting were 75.1 for OLD, 79.6 for PAH, 91.0 for CF, and 88.3 for ILD (p < 0.001).
conclusionsAmong patients bridging to transplant on ECMO, patients with PAH had a lower transplantation rate than patients with OLD, CF, and ILD.
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