Evidence map›Paper›PMID 34548133›Full record

ReviewCritical care clinics2021

COVID-19-Associated Acute Respiratory Distress Syndrome: Lessons from Tissues and Cells.

Elizabeth A Middleton, Guy A Zimmerman

Open access · bronzeAbstract readReview
In one paragraph

Review in Critical care clinics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. A decoy mutant ACE2 designed to reduce COVID-19.Trends in pharmacological sciences · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth A MiddletonDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Program in Molecular Medicine, University of Utah School of Medicine, Eccles Institute of Human Genetics, 15 North 2030 East, Room #4220, Salt Lake City, UT 84112, USA.
Guy A ZimmermanDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Program in Molecular Medicine, University of Utah School of Medicine, Eccles Institute of Human Genetics, 15 North 2030 East, Room #4220, Salt Lake City, UT 84112, USA. Electronic address: guy.zimmerman@u2m2.utah.edu.
University of Utah · US

Funding

Novel vascular guidance mechanismsR01HL077671 · NHLBI · UNIVERSITY OF UTAH · PI ZHU, WEIQUAN (WENDY) · 2004 to 2017
$4.3M
New Therapies to Restore Vascular Integrity During SepsisR01HL130541 · NHLBI · UNIVERSITY OF UTAH · PI ODELBERG, SHANNON J, WEYRICH, ANDREW S · 2016 to 2020
$3.7M
Molecular Interactions of Myeloid Cells with EndotheliumR37HL044525 · NHLBI · UNIVERSITY OF UTAH · PI ZIMMERMAN, GUY A. · 2004 to 2013
$3.5M
NETs: Protection or Harm in Neonatal Inflammation and InfectionR01HD093826 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI CHRISTIAN CON YOST · 2018 to 2026
$2.6M
The regulation and function of platelet FcARIIA in sepsisK08HL153953 · NHLBI · UNIVERSITY OF UTAH · PI MIDDLETON, ELIZABETH ANNE · 2020 to 2024
$833k
NHLBI NIH HHS K08 HL153953NHLBI NIH HHS R01 HL077671NHLBI NIH HHS R01 HL130541NHLBI NIH HHS R37 HL044525NICHD NIH HHS R01 HD093826
6 · The paper itself

Abstract

Reports examining lung histopathology in coronavirus disease 2019 (COVID-19) infection provide an essential body of information for clinicians and investigators. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-induced lung injury is complex, involving the airways, alveoli, and pulmonary vessels. Although no anatomic marker is specific, the signature histologic lesion is diffuse alveolar damage (DAD). The biological and molecular mechanisms that drive this pattern of injury are unknown, and the relationship of SARS-CoV-2-induced DAD to physiologic alterations and clinical outcomes in COVID-19-associated acute respiratory distress syndrome is undefined. Additional histologic patterns that may be variant phenotypes have been reported.

Indexed as

COVID-19Respiratory Distress SyndromeHumansLungSARS-CoV-2Acute lung injuryARDSCOVID-19HistopathologySARS-CoV-2Vasculopathy

Identifiers

PMID34548133
PMCPMC8149203
OpenAlexW3163958518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.