Evidence map›Paper›PMID 34548116›Full record

Trial reportJournal of the International Neuropsychological Society : JINS2021

The Effect of Aerobic Exercise on Concussion Recovery: A Pilot Clinical Trial.

Aliyah R Snyder, Sarah M Greif, James R Clugston, David B FitzGerald, Joshua F Yarrow, Talin Babikian, Christopher C Giza, Floyd J Thompson, Russell M Bauer

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the International Neuropsychological Society : JINS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05860023 (Effect of Pelvic Floor Muscle Strengthening and Aerobic Exercises on Uterus Involution), which is not on this map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05860023 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Pelvic Floor Muscle Strengthening and Aerobic Exercises on Uterus Involution

TypeinterventionalSponsorBitlis Eren UniversityRan2023 to 2023Enrolled45ConditionsUterus InvolutionArmsExercise
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aliyah R SnyderDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-1185-7424
Sarah M GreifDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
James R ClugstonDepartment of Community Health and Family Medicine, University of Florida, Gainesville, FL, USA.
David B FitzGeraldDepartment of Neurology, University of Florida, Gainesville, FL, USA.
Joshua F YarrowResearch Service and Brain Rehabilitation Research Center, Malcolm Randall VA Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
Talin BabikianDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.
Christopher C GizaUCLA Steve Tisch BrainSPORT Program, University of California, Los Angeles, Los Angeles, CA, USA.
Floyd J ThompsonResearch Service and Brain Rehabilitation Research Center, Malcolm Randall VA Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL, USA.
Russell M BauerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.

Funding

UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
UF Clinical and Translational Science AwardTL1TR000066 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$345k
MOTOR CORRELATES OF ONTOGENYF32NS009229 · NINDS · INDIANA UNIVERSITY BLOOMINGTON · PI ALLAN, SUSAN E · 1992 to 1994
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NCATS NIH HHS TL1 TR000066NCATS NIH HHS UL1 TR000064NINDS NIH HHS F32 NS009229
6 · The paper itself

Abstract

objectiveThe purpose of this study was to pilot safety and tolerability of a 1-week aerobic exercise program during the post-acute phase of concussion (14-25 days post-injury) by examining adherence, symptom response, and key functional outcomes (e.g., cognition, mood, sleep, postural stability, and neurocognitive performance) in young adults.

methodA randomized, non-blinded pilot clinical trial was performed to compare the effects of aerobic versus non-aerobic exercise (placebo) in concussion patients. The study enrolled three groups: 1) patients with concussion/mild traumatic brain injury (mTBI) randomized to an aerobic exercise intervention performed daily for 1-week, 2) patients with concussion/mTBI randomized to a non-aerobic (stretching and calisthenics) exercise program performed daily for 1-week, and 3) non-injured, no intervention reference group.

resultsMixed-model analysis of variance results indicated a significant decrease in symptom severity scores from pre- to post-intervention (mean difference = -7.44, 95% CI [-12.37, -2.20]) for both concussion groups. However, the pre- to post-change was not different between groups. Secondary outcomes all showed improvements by post-intervention, but no differences in trajectory between the groups. By three months post-injury, all outcomes in the concussion groups were within ranges of the non-injured reference group.

conclusionsResults from this study indicate that the feasibility and tolerability of administering aerobic exercise via stationary cycling in the post-acute time frame following post-concussion (14-25 days) period are tentatively favorable. Aerobic exercise does not appear to negatively impact recovery trajectories of neurobehavioral outcomes; however, tolerability may be poorer for patients with high symptom burden.

Indexed as

Athletic InjuriesBrain ConcussionPost-Concussion SyndromeExerciseExercise TherapyHumansYoung AdultBrain InjuriesFeasibility StudiesNeuropsychologyPublic HealthReturn to SportSports

Identifiers

PMID34548116
PMCPMC8601125

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.