Evidence map›Paper›PMID 34548110›Full record

ArticleTrials2021

Transcranial direct current stimulation (tDCS) in addition to walking training on walking, mobility, and reduction of falls in Parkinson's disease: study protocol for a randomized clinical trial.

Lucas Rodrigues Nascimento, Ester Miyuki Nakamura-Palacios, Augusto Boening, Bárbara Naeme Lima Cordeiro, Daniel Lyrio Cabral, Alessandra Swarowsky, Guilherme Peixoto Tinoco Arêas, Wellingson Silva Paiva, Fernando Zanela da Silva Arêas

Erratum issuedAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lucas Rodrigues NascimentoCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES), 1468 Marechal Campos Avenue, Maruípe, Vitória, ES, 29043900, Brazil.
Ester Miyuki Nakamura-PalaciosLaboratory of Cognitive Sciences and Neuropsychopharmacology, Department of Physiological Sciences, Universidade Federal do Espírito Santo (UFES), Vitória, ES, Brazil.
Augusto BoeningCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES), 1468 Marechal Campos Avenue, Maruípe, Vitória, ES, 29043900, Brazil.
Bárbara Naeme Lima CordeiroCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES), 1468 Marechal Campos Avenue, Maruípe, Vitória, ES, 29043900, Brazil.
Daniel Lyrio CabralCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES), 1468 Marechal Campos Avenue, Maruípe, Vitória, ES, 29043900, Brazil.
Alessandra SwarowskyDepartment of Physical Therapy, Universidade Estadual de Santa Catarina (UDESC), Florianópolis, SC, Brazil.
Guilherme Peixoto Tinoco ArêasDepartment of Human Physiology, Universidade Federal do Amazonas (UFAM), Manaus, AM, Brazil.
Wellingson Silva PaivaNeurosurgery Division, Department of Neurology, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Fernando Zanela da Silva ArêasCenter of Health Sciences, Discipline of Physical Therapy, Universidade Federal do Espírito Santo (UFES), 1468 Marechal Campos Avenue, Maruípe, Vitória, ES, 29043900, Brazil. fernandozanela@hotmail.com.ORCID http://orcid.org/0000-0002-2068-2606

Funding

21/2018 Universal
6 · The paper itself

Abstract

backgroundTranscranial direct current stimulation (tDCS) has the potential to modulate cortical excitability and enhance the effects of walking training in people with Parkinson's disease. This study will examine the efficacy of the addition of tDCS to a task-specific walking training to improve walking and mobility and to reduce falls in people with Parkinson's disease.

methodsThis is a two-arm, prospectively registered, randomized trial with concealed allocation, blinded assessors, participants and therapists, and intention-to-treat analysis. Twenty-four individuals with Parkinson's disease, categorized as slow or intermediate walkers (walking speeds ≤ 1.0 m/s), will be recruited. The experimental group will undertake a 30-min walking training associated with tDCS, for 4 weeks. The control group will undertake the same walking training, but with sham-tDCS. The primary outcome will be comfortable walking speed. Secondary outcomes will include walking step length, walking cadence, walking confidence, mobility, freezing of gait, fear of falling, and falls. Outcomes will be collected by a researcher blinded to group allocation at baseline (week 0), after intervention (week 4), and 1 month beyond intervention (week 8). DISCUSSION: tDCS associated with walking training may help improve walking of slow and intermediate walkers with Parkinson's disease. If walking is enhanced, the benefits may be accompanied by better mobility and reduced fear of falling, and individuals may experience greater free-living physical activity at home and in the community.

trial registrationBrazilian Registry of Clinical Trials (ReBEC) RBR-6bvnx6 . Registered on September 23, 2019.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseTranscranial Direct Current StimulationAccidental FallsExercise TherapyFearHumansRandomized Controlled Trials as TopicWalkingClinical trialGaitParkinsonRehabilitationTranscranial direct current stimulation

Identifiers

PMID34548110
PMCPMC8454107

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.