Evidence map›Paper›PMID 34548105›Full record

ArticleParasites & vectors2021

Microarray analysis of circular RNAs in HCT-8 cells infected with Cryptosporidium parvum.

Yuqing Wang, Heng Zhao, Yanan Zhang, Lei Yan

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuqing WangSchool of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Heng ZhaoSchool of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Yanan ZhangCenter for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Lei YanSchool of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. yanlei@sdu.edu.cn.ORCID http://orcid.org/0000-0002-3333-8556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We read with great interest the article by Yin et al. (Parasit Vectors 14:238, 2021). The authors found that Cryptosporidium infection induced significantly aberrant expression of circular RNA profiles in HCT-8 cells, a finding which has far-reaching implications. However, due to the high number of false positives caused by multiple comparisons, statistical methods for microarray analysis should be carefully selected. Accurate analysis results will provide a convincing basis for subsequent experiments. In addition, we recommend several more appropriate methods in this article.

Indexed as

Cell Line, TumorCryptosporidiosisCryptosporidium parvumHumansMicroarray AnalysisRNA, CircularRNA, ProtozoanRNA, CircularRNA, ProtozoanBioinformaticsCryptosporidium parvumMicroarrayStatistics

Identifiers

PMID34548105
PMCPMC8456637

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.