Evidence map›Paper›PMID 34548098›Full record

ReviewBioelectronic medicine2021

Historical perspectives, challenges, and future directions of implantable brain-computer interfaces for sensorimotor applications.

Santosh Chandrasekaran, Matthew Fifer, Stephan Bickel, Luke Osborn, Jose Herrero, Breanne Christie, Junqian Xu, Rory K J Murphy, Sandeep Singh, Matthew F Glasser and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Bioelectronic medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. In vivo microelectrode arrays for neuroscience.Nature reviews. Methods primers · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Santosh ChandrasekaranNeural Bypass and Brain Computer Interface Laboratory, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Matthew FiferResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
Stephan BickelThe Human Brain Mapping Laboratory, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Luke OsbornResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
Jose HerreroThe Human Brain Mapping Laboratory, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Breanne ChristieResearch and Exploratory Development Department, Johns Hopkins University Applied Physics Laboratory, Laurel, MD, USA.
Junqian XuDepartments of Radiology and Psychiatry, Baylor College of Medicine, Houston, TX, USA.
Rory K J MurphyDepartment of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Sandeep SinghGood Shepherd Rehabilitation Hospital, Allentown, PA, USA.
Matthew F GlasserDepartments of Radiology and Neuroscience, Washington University in St Louis, Saint Louis, MO, USA.
Jennifer L CollingerRehabilitation Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Robert GauntRehabilitation Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Ashesh D MehtaThe Human Brain Mapping Laboratory, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA.
Andrew SchwartzMcGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Chad E BoutonNeural Bypass and Brain Computer Interface Laboratory, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA. cbouton@northwell.edu.ORCID http://orcid.org/0000-0002-6297-3890

Funding

RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7M
NIMH NIH HHS R01 MH060974
6 · The paper itself

Abstract

Almost 100 years ago experiments involving electrically stimulating and recording from the brain and the body launched new discoveries and debates on how electricity, movement, and thoughts are related. Decades later the development of brain-computer interface technology began, which now targets a wide range of applications. Potential uses include augmentative communication for locked-in patients and restoring sensorimotor function in those who are battling disease or have suffered traumatic injury. Technical and surgical challenges still surround the development of brain-computer technology, however, before it can be widely deployed. In this review we explore these challenges, historical perspectives, and the remarkable achievements of clinical study participants who have bravely forged new paths for future beneficiaries.

Identifiers

PMID34548098
PMCPMC8456563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.