Evidence map›Paper›PMID 34547772›Full record

ArticleBlood advances2021

CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes.

Benjamin J Huang, Jenny L Smith, Yi-Cheng Wang, Kassra Taghizadeh, Amanda R Leonti, Rhonda E Ries, Yanling Liu, Pandurang Kolekar, Katherine Tarlock, Robert Gerbing and 14 more

Abstract read
In one paragraph

Article in Blood advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Hematopoietic Stem Cell Transplantation Outcomes for High-Risk AML: A Report From the Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Trial
  2. Genes · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Benjamin J HuangDepartment of Pediatrics, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-6996-0833
Jenny L SmithFred Hutchinson Cancer Research Center, Seattle, WA.
Yi-Cheng WangChildren's Oncology Group, Monrovia, CA.
Kassra TaghizadehFred Hutchinson Cancer Research Center, Seattle, WA.
Amanda R LeontiFred Hutchinson Cancer Research Center, Seattle, WA.
Rhonda E RiesFred Hutchinson Cancer Research Center, Seattle, WA.
Yanling LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Pandurang KolekarDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-0044-0076
Katherine TarlockFred Hutchinson Cancer Research Center, Seattle, WA.
Robert GerbingChildren's Oncology Group, Monrovia, CA.
Erin CrowgeyNemours Center for Cancer and Blood Disorders and Alfred I. DuPont Hospital for Children, Wilmington, DE.ORCID 0000-0002-2037-0389
Scott N FurlanFred Hutchinson Cancer Research Center, Seattle, WA.
Timothy I ShawDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-9316-1924
Kohei HagiwaraDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Lisa WeiMichael Smith Genome Sciences Centre, Vancouver, BC, Canada.
Todd M CooperDivision of Hematology/Oncology, Seattle Children's Hospital, Seattle, WA.
Alan S GamisChildren's Mercy Hospitals and Clinics, Kansas City, MO.ORCID 0000-0003-1513-2893
Richard AplencChildren's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-7482-5644
E Anders KolbNemours Center for Cancer and Blood Disorders and Alfred I. DuPont Hospital for Children, Wilmington, DE.
Jason E FarrarUniversity of Arkansas for Medical Sciences & Arkansas Children's Research Institute, Little Rock, AR.ORCID 0000-0003-2148-5839
Timothy TricheVan Andel Research Institute, Grand Rapids, MI; and.
Todd A AlonzoDepartment of Preventive Medicine, University of Southern California, Los Angeles, CA.
Xiaotu MaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Soheil MeshinchiFred Hutchinson Cancer Research Center, Seattle, WA.

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG FOREIGN ACCRUALU10CA098543 · NCI · NATIONAL CHILDHOOD CANCER FOUNDATION · PI ADAMSON, PETER C. · 2003 to 2013
$335.5M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Biology/prognostic implications of Flt3 mutations in AMLR01CA114563 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MESHINCHI, SOHEIL · 2005 to 2016
$4.4M
High-Performance Compute Cluster for Comprehensive Cancer and Infectious Diseases ResearchS10OD028685 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BRADLEY, PHILIP · 2020 to 2020
$2.0M
Co-targeting BET Bromodomain Proteins and Aberrant Signaling in AML.K08CA256489 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, BENJAMIN · 2021 to 2025
$1.2M
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS K08 CA256489NCI NIH HHS R01 CA114563NCI NIH HHS U10 CA098543NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NIH HHS S10 OD028685
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Myeloid, AcuteCore Binding Factor beta SubunitHumansMyosin Heavy ChainsOncogene Proteins, FusionCBFB protein, humanCore Binding Factor beta SubunitMYH11 protein, humanMyosin Heavy ChainsOncogene Proteins, Fusion

Identifiers

PMID34547772
PMCPMC9153007

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.