Evidence map›Paper›PMID 34547760›Full record

ArticleExercise and sport sciences reviews2021

Bioenergetic Mechanisms Linking V˙O2 Kinetics and Exercise Tolerance.

Richie P Goulding, Harry B Rossiter, Simon Marwood, Carrie Ferguson

Abstract read
In one paragraph

Article in Exercise and sport sciences reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Exercise training-induced speeding ofEuropean journal of applied physiology · 2025
    Trial
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Reliability and applicability of theEuropean journal of applied physiology · 2025
    Article
  11. Article
  12. Article
  13. VOLupus · 2025
    Article
  14. Article
  15. Biochemical origin of (near-) linear curvature constant (W')-European journal of applied physiology · 2025
    Article
  16. Frontiers in physiology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Richie P Goulding
Harry B RossiterRehabilitation Clinical Trials Center, Division of Respiratory & Critical Care Physiology & Medicine, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Simon MarwoodSchool of Health Sciences, Liverpool Hope University, Liverpool.
Carrie FergusonSchool of Biomedical Sciences, Faculty of Biological Sciences & Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK.

Funding

Mechanism Underlying the Transduction of Epimutations from the Soma to the Male GermlineP50HD098593 · NICHD · UNIVERSITY OF NEVADA RENO · PI YAN, WEI · 2019 to 2024
$7.2M
Rehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M · 2015 to 2019
$7.1M
A Randomized Controlled Trial of Thyroid Hormone Supplementation in Hemodialysis PatientsR01DK122767 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RHEE, CONNIE MEEYOUNG · 2019 to 2023
$3.3M
Determinants of 5 Year Progression of Muscle Dysfunction and Inactivity in COPDGene Participants Diversity SupplementR01HL151452 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI ADAMI, ALESSANDRA, ROSSITER, HARRY B · 2020 to 2023
$1.6M
NHLBI NIH HHS R01 HL151452NICHD NIH HHS P2C HD086851NICHD NIH HHS P50 HD098593NIDDK NIH HHS R01 DK122767
6 · The paper itself

Abstract

We hypothesize that the V˙O2 time constant (τV˙O2) determines exercise tolerance by defining the power output associated with a "critical threshold" of intramuscular metabolite accumulation (e.g., inorganic phosphate), above which muscle fatigue and work inefficiency are apparent. Thereafter, the V˙O2 "slow component" and its consequences (increased pulmonary, circulatory, and neuromuscular demands) determine performance limits.

Indexed as

Exercise ToleranceOxygen ConsumptionEnergy MetabolismExercise TestHumansKineticsMuscle, Skeletal

Identifiers

PMID34547760
PMCPMC8528340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.