Evidence map›Paper›PMID 34547717›Full record

ArticleAmerican journal of otolaryngology

COVID associated mucormycosis: A preliminary study from a dedicated COVID Hospital in Delhi.

Ravi Meher, Vikram Wadhwa, Vikas Kumar, Daphylla Shisha Phanbuh, Raman Sharma, Ishwar Singh, P K Rathore, Ruchi Goel, Ritu Arora, Sandeep Garg and 8 more

Open access · greenAbstract read
In one paragraph

Article in American journal of otolaryngology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Outcomes of COVID-19-associated mucormycosis epidemic in India: A prospective 2-year follow-up study.World journal of otorhinolaryngology - head and neck surgery · 2025
    Article
  3. Article
  4. A Comparative Study of Acute Invasive Fungal Sinusitis During the First and Second Waves of the COVID-19 Pandemic.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. A comparative study on the clinical profile of COVID-related and non-COVID-related acute invasive fungal rhino sinusitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Ravi MeherMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Vikram WadhwaMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Vikas KumarMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India. Electronic address: vikaskumar2890@yahoo.com.
Daphylla Shisha PhanbuhMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Raman SharmaMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Ishwar SinghMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
P K RathoreMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Ruchi GoelMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Ritu AroraMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Sandeep GargMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Suresh KumarMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Jyoti KumarMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Munisha AgarwalMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Meeta SinghMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Nita KhuranaMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Tanu SagarMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Vikas ManchandaMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Sonal SaxenaMaulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Maulana Azad Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt is an incontrovertible fact that the Rhino Orbital Cerebral Mucormycosis (ROCM) upsurge is being seen in the context of COVID-19 in India. Briefly presented is evidence that in patients with uncontrolled diabetes, a dysfunctional immune system due to SARS-COV-2 and injudicious use of corticosteroids may be largely responsible for this malady.

objectiveTo find the possible impact of COVID 19 infection and various co-morbidities on occurrence of ROCM and demonstrate the outcome based on medical and surgical interventions. METHODOLOGY: Prospective longitudinal study included patients diagnosed with acute invasive fungal rhinosinusitis after a recent COVID-19 infection. Diagnostic nasal endoscopy (DNE) was performed on each patient and swabs were taken and sent for fungal KOH staining and microscopy. Medical management included Injection Liposomal Amphotericin B, Posaconazole and Voriconazole. Surgical treatment was restricted to patients with RT PCR negative results for COVID-19. Endoscopic, open, and combined approaches were utilized to eradicate infection. Follow-up for survived patients was maintained regularly for the first postoperative month.

resultsOut of total 131 patients, 111 patients had prior history of SARS COVID 19 infection, confirmed with a positive RT-PCR report and the rest 20 patients had no such history. Steroids were received as a part of treatment in 67 patients infected with COVID 19. Among 131 patients, 124 recovered, 1 worsened and 6 died. Out of 101 known diabetics, 98 recovered and 3 had fatal outcomes. 7 patients with previous history of COVID infection did not have any evidence of Diabetes mellitus, steroid intake or any other comorbidity.

conclusionIt can be concluded that ROCM upsurge seen in the context of COVID-19 in India was mainly seen in patients with uncontrolled diabetes, a dysfunctional immune system due to SARS-COV-2 infection and injudicious use of corticosteroids.

Indexed as

Adrenal Cortex HormonesAntifungal AgentsCOVID-19Diabetes ComplicationsDiagnostic ImagingEndoscopyFemaleHumansIndiaLongitudinal StudiesMaleMiddle AgedMucormycosisPandemicsProspective StudiesRisk FactorsAdrenal Cortex HormonesAntifungal AgentsAcute invasive fungal sinusitisCOVID-19Diabetes mellitusMucormycosis

Identifiers

PMID34547717
PMCPMC8432976
OpenAlexW3199993627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.