ArticleNeuropharmacology2021
Activation of locus coeruleus to rostromedial tegmental nucleus (RMTg) noradrenergic pathway blunts binge-like ethanol drinking and induces aversive responses in mice.
Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Nociceptive responses and resting-state functional connectivity of the human midbrain tegmentum.Brain structure & function · 2026Article
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Nociceptive Responses and Resting-State Functional Connectivity of the Human Midbrain Tegmentum.Research square · 2026Article
- Activation of a locus coeruleus to ventral tegmental area noradrenergic pathway blunts binge-like ethanol intake and promotes aversive unconditioned responses in TH-ires-Cre mice.Neuropharmacology · 2026Article
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- Acoustic features of and behavioral responses to emotionally intense mouse vocalizations.Behavioural brain research · 2026Article
- Alpha-2 Adrenergic Agonists Reduce Heavy Alcohol Drinking and Improve Cognitive Performance in Mice.eNeuro · 2026Article
- Noradrenergic Mechanisms and Circuitry of Hyperkatifeia in Alcohol Use Disorder.Biological psychiatry · 2025Review
- Corticotropin-Releasing Factor Modulates Binge-Like Ethanol Drinking in a Sex-Dependent Manner: Impact of Amygdala Deletion and Inhibition of a Central Amygdala to Lateral Hypothalamus Circuit.Biological psychiatry global open science · 2025Article
- Neural Circuitries and Alcohol Use Disorder: Cutting Corners in the Cycle.Current topics in behavioral neurosciences · 2025Review
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- Basolateral amygdala neuropeptide Y system modulates binge ethanol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Chemogenetic inhibition of locus coeruleus to rostromedial tegmental nucleus noradrenergic pathway increases light cycle ethanol drinking in male and female mice and blunts ethanol-induced CTA.Neuropharmacology · 2024Article
- The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats.Psychopharmacology · 2023Article
- Chronic ethanol alters adrenergic receptor gene expression and produces cognitive deficits in male mice.Neurobiology of stress · 2023Article
- GABAergic neurons in the rostromedial tegmental nucleus are essential for rapid eye movement sleep suppression.Nature communications · 2022Article
- The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking.eLife · 2022Article
- Lateral habenula-projecting central amygdala circuits expressing GABA and NPY Y1 receptor modulate binge-like ethanol intake in mice.Addiction neuroscience · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There is strong evidence that ethanol entails aversive effects that can act as a deterrent to overconsumption. We have found that in doses that support the development of a conditioned taste aversion ethanol increases the activity of tyrosine hydroxylase (TH) positive neurons in the locus coeruleus (LC), a primary source of norepinephrine (NE). Using cre-inducible AAV8-ChR2 viruses in TH-ires-cre mice we found that the LC provides NE projections that innervate the rostromedial tegmental nucleus (RMTg), a brain region that has been implicated in the aversive properties of drugs. Because the neurocircuitry underlying the aversive effects of ethanol is poorly understood, we characterized the role of the LC to RMTg circuit in modulating aversive unconditioned responses and binge-like ethanol intake. Here, both male and female TH-ires-cre mice were cannulated in the RMTg and injected in the LC with rAVV viruses that encode for a Gq-expressing designer receptor exclusively activated by designer drugs (DREADDs) virus, or its control virus, to directly control the activity of NE neurons. A Latin Square paradigm was used to analyze both 20% ethanol and 3% sucrose consumption using the "drinking-in-the-dark" (DID) paradigm. Chemogenetic activation of the LC to RMTg pathway significantly blunted the binge-ethanol drinking, with no effect on the sucrose consumption, increased the emission of mid-frequency vocalizations and induced malaise-like behaviors in mice. The present findings indicate an important involvement of the LC to RMTg pathway in reducing ethanol consumption, and characterize unconditioned aversive reactions induced by activation of this noradrenergic pathway.
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