Evidence map›Paper›PMID 34547202›Full record

ArticleACS applied materials & interfaces2021

Controlling the Biological Fate of Liposomal Spherical Nucleic Acids Using Tunable Polyethylene Glycol Shells.

Wuliang Zhang, Cassandra E Callmann, Chad A Mirkin

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wuliang ZhangDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0001-8769-5914
Cassandra E CallmannDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0003-1561-3240
Chad A MirkinDepartment of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States.ORCID https://orcid.org/0000-0002-6634-7627

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
STINGing GBM: A First-in- Man Clinical Trial in Surgical Resectable Recurrent GBMP50CA221747 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Atique U. Ahmed · 2018 to 2026
$21.4M
Project 3: Spherical Nucleic Acids as Immunotherapeutic Agents for Prostate CancerU54CA199091 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2015 to 2019
$11.7M
Systemic RNA interference to reactivate p53 tumor suppressionR01CA208783 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A., STEGH, ALEXANDER H. · 2017 to 2021
$1.8M
NCI NIH HHS P30 CA060553NCI NIH HHS P50 CA221747NCI NIH HHS R01 CA208783NCI NIH HHS U54 CA199091
6 · The paper itself

Abstract

Liposomal spherical nucleic acids (LSNAs) modified with polyethylene glycol (PEG) units are studied in an attempt to understand how the circulation time and biodistribution of the constructs can be manipulated. Specifically, the effect of (1) PEG molecular weight, (2) PEG shell stability, and (3) PEG modification method (PEG in both the core and shell versus PEG in the shell only) on LSNA blood circulation, biodistribution, and

Indexed as

AnimalsCell Line, TumorFemaleHumansImmobilized Nucleic AcidsLiposomesMiceMice, Inbred BALB CMolecular WeightOligodeoxyribonucleotidesPhosphatidylcholinesPolyethylene GlycolsTissue Distribution1,2-oleoylphosphatidylcholineImmobilized Nucleic AcidsLiposomesOligodeoxyribonucleotidesPhosphatidylcholinesPolyethylene GlycolsliposomesPEGylationspherical nucleic acidsstructure−function analysistriple-negative breast cancer

Identifiers

PMID34547202
PMCPMC8590845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.