Evidence map›Paper›PMID 34547110›Full record

ArticleAllergy2022

Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers.

Debbie J Maurer, Chengyao Liu, Paraskevi Xepapadaki, Barbara Stanic, Claus Bachert, Susetta Finotto, Ya-Dong Gao, Anna Graser, Tuomas Jartti, Walter Kistler and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Managing childhood asthma with an eye toward environmental, social, and behavioral features.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 8 countries.

Debbie J MaurerSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0002-8543-1998
Chengyao LiuSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0002-0056-9032
Paraskevi XepapadakiAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0001-9204-1923
Barbara StanicSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.
Claus BachertUpper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0003-4742-1665
Susetta FinottoDepartment of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.ORCID 0000-0001-7623-7977
Ya-Dong GaoDepartment of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.ORCID 0000-0003-1251-7608
Anna GraserDepartment of Molecular Pneumology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Universitätsklinikum Erlangen, Erlangen, Germany.
Tuomas JarttiDepartment of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0003-2748-5362
Walter KistlerSwiss Research Institute for Sports Medicine (SRISM), Davos, Switzerland.ORCID 0000-0002-9289-6953
Marek KowalskiDepartment of Immunology, Rheumatology and Allergy, Central University Hospital, Lodz, Poland.ORCID 0000-0002-8442-2774
Heikki LukkarinenDepartment of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Maria PasiotiAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
Ge TanSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0003-0026-8739
Michael VilligerSwiss Research Institute for Sports Medicine (SRISM), Davos, Switzerland.
Luo ZhangDepartment of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-0910-9884
Nan ZhangUpper Airway Research Laboratory, Ghent University Hospital, Ghent, Belgium.
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0003-0554-9943
Nikolaos G PapadopoulosAllergy Department, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0002-4448-3468
Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.ORCID 0000-0001-8020-019X
University of Zurich · CHNational and Kapodistrian University of Athens · GRBeijing Tongren Hospital · CNGhent University Hospital · BEUniversitätsklinikum Erlangen · DEUniversity of Turku · FICentral Clinical Hospital · PLWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical activity and daily TV attendance, to assess its role on asthma control and immune responses to various immune stimulants.

methodsWeekly physical activity and daily television attendance were obtained from questionnaires at inclusion of the PreDicta study. PBMC cultures were stimulated with phytohemagglutinin (PHA), R848, poly I:C, and zymosan. A panel of cytokines was measured and quantified in cell culture supernatants using luminometric multiplex immunofluorescence beads-based assay.

resultsAsthmatic preschoolers showed significantly more TV attendance than their healthy peers (58.6% vs. 41.5% 1-3 h daily and only 25.7% vs. 47.2% ≤1 h daily) and poor asthma control was associated with less frequent physical activity (PA) (75% no or occasional activity in uncontrolled vs. 20% in controlled asthma; 25% ≥3 times weekly vs. 62%). Asthmatics with increased PA exhibited elevated cytokine levels in response to polyclonal stimulants, suggesting a readiness of circulating immune cells for type 1, 2, and 17 cytokine release compared to subjects with low PA and high TV attendance. This may also represent a proinflammatory state in high PA asthmatic children. Low physical activity and high TV attendance were associated with a decrease in proinflammatory cytokines. Proinflammatory cytokines were correlating with each other in in vitro immune responses of asthmatic children, but not healthy controls, this correlation was more pronounced in children with sedentary behavior.

conclusionAsthmatic children show more sedentary behavior than healthy subjects, while poor asthma control is associated with a substantial decrease in physical activity. Our results suggest that asthmatic children may profit from regular exercise, as elevated cytokine levels in stimulated conditions indicate an immune system prepared for responding strongly in case of different types of infections. However, it has to be considered that a hyperinflammatory state in high PA may not be beneficial in asthmatic children.

Indexed as

AsthmaLeukocytes, MononuclearChildCytokinesExerciseHumansImmunityCytokinesasthmacytokinesimmune modulationphysical activityPreDicta

Identifiers

PMID34547110
PMCPMC9291774
OpenAlexW3169450628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.