Evidence map›Paper›PMID 34546729›Full record

ArticleJournal of the American Chemical Society2021

A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.

Sven Epple, Aman Modi, Ysobel R Baker, Ewa Wȩgrzyn, Diallo Traoré, Przemyslaw Wanat, Agnes E S Tyburn, Arun Shivalingam, Lapatrada Taemaitree, Afaf H El-Sagheer and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Two-Step Validation Approach for Tools To Study the DNA Repair Enzyme SNM1A.Chembiochem : a European journal of chemical biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sven EppleChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0002-9078-3250
Aman ModiChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0002-6174-7189
Ysobel R BakerChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0002-0266-771X
Ewa WȩgrzynChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0001-8929-046X
Diallo TraoréChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.
Przemyslaw WanatChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.
Agnes E S TyburnChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.
Arun ShivalingamChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.
Lapatrada TaemaitreeChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0002-6359-4534
Afaf H El-SagheerChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0001-8706-1292
Tom BrownChemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.ORCID 0000-0002-6538-3036

Funding

Biotechnology and Biological Sciences Research Council BB/R008655/1Biotechnology and Biological Sciences Research Council BB/S018794/1
6 · The paper itself

Abstract

Triazole linkages (TLs) are mimics of the phosphodiester bond in oligonucleotides with applications in synthetic biology and biotechnology. Here we report the RuAAC-catalyzed synthesis of a novel 1,5-disubstituted triazole (TL

Indexed as

CatalysisDinucleoside PhosphatesDNADNA-Directed DNA PolymeraseMolecular MimicryTriazolesDinucleoside PhosphatesDNADNA-Directed DNA PolymeraseTriazoles

Identifiers

PMID34546729
PMCPMC8499026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.