Evidence map›Paper›PMID 34546637›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2022

Enhanced detection of abnormalities in heart rate variability and dynamics by 7-day continuous ECG monitoring.

Junichiro Hayano, Emi Yuda

Open access · goldAbstract read
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Seven-Day Patch ECG Monitoring During National Insurance Health Checkup Efficiently Detected Silent Atrial Fibrillation in Individuals Aged 75 Years and Older.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025
    Article
  3. Enhanced detection of abnormalities in heart rate variability and dynamics by 7-day continuous ECG monitoring.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Junichiro HayanoHeart Beat Science Lab, Co., Ltd., Sendai, Japan.ORCID 0000-0002-5340-6325
Emi YudaHeart Beat Science Lab, Co., Ltd., Sendai, Japan.
Nagoya City University · JPTohoku University · JP

Funding

Heart Beat Science Lab Co., Ltd., Japan
6 · The paper itself

Abstract

backgroundThe analysis of heart rate variability (HRV) and heart rate (HR) dynamics by Holter ECG has been standardized to 24 hs, but longer-term continuous ECG monitoring has become available in clinical practice. We investigated the effects of long-term ECG on the assessment of HRV and HR dynamics.

methodsIntraweek variations in HRV and HR dynamics were analyzed in 107 outpatients with sinus rhythm. ECG was recorded continuously for 7 days with a flexible, codeless, waterproof sensor attached on the upper chest wall. Data were divided into seven 24-h segments, and standard time- and frequency-domain HRV and nonlinear HR dynamics indices were computed for each segment.

resultsThe intraweek coefficients of variance of HRV and HR dynamics indices ranged from 2.9% to 26.0% and were smaller for frequency-domain than for time-domain indices, and for indices reflecting slower HR fluctuations than faster fluctuations. The indices with large variance often showed transient abnormalities from day to day over 7 days, reducing the positive predictive accuracy of the 24-h ECG for detecting persistent abnormalities over 7 days. Conversely, 7-day ECG provided 2.3- to 6.5-fold increase in sensitivity to detect persistent plus transient abnormalities compared with 24-h ECG. It detected an average of 1.74 to 2.91 times as many abnormal indices as 24-h ECG.

conclusionsLong-term ECG monitoring increases the accuracy and sensitivity of detecting persistent and transient abnormalities in HRV and HR dynamics and allows discrimination between the two types of abnormalities. Whether this discrimination improves risk stratification deserves further studies.

Indexed as

ElectrocardiographyElectrocardiography, AmbulatoryHeart RateHumansday-to-day variationheart rate dynamicsheart rate variabilityHolter ECGintraweek variationlong-term ECG monitoring

Identifiers

PMID34546637
PMCPMC8739595
OpenAlexW3200459334

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.