Evidence map›Paper›PMID 34546582›Full record

ArticleCell proliferation2021

Mitochondrial Calcium uniporters are essential for meiotic progression in mouse oocytes by controlling Ca

Lu Yao Zhang, Meng Lin, Zhuan Qingrui, Wang Zichuan, Li Junjin, Liu Kexiong, Fu Xiangwei, Hou Yunpeng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  4. Review
  5. Mitochondrial CaFrontiers in cell and developmental biology · 2026
    Review
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Lu Yao ZhangState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Meng LinState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhuan QingruiKey Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0003-2797-0472
Wang ZichuanState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Li JunjinState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Liu KexiongState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Fu XiangweiKey Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Hou YunpengState Key Laboratories of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-6807-8336
China Agricultural University · CNBeijing University of Agriculture · CNXinjiang Academy of Agricultural and Reclamation Science · CN

Funding

The National Major Project for Production of Transgenic Breeding 2018ZX08007001
6 · The paper itself

Abstract

objectivesThe alteration of bioenergetics by oocytes in response to the demands of various biological processes plays a critical role in maintaining normal cellular physiology. However, little is known about the association between energy sensing and energy production with energy-dependent cellular processes like meiosis. MATERIALS AND

methodsWe demonstrated that cell cycle-dependent mitochondrial Ca

resultsDecreased numbers of oocytes successfully progressed to the germinal vesicle stage and extruded the first polar body during in vitro culture after inhibition, while spindle checkpoint-dependent meiosis was also delayed. Mitochondrial Ca

conclusionsThese data provide new insight into the protective role that MCU-dependent mitochondrial Ca

Indexed as

AMP-Activated Protein KinasesAnimalsCalcium ChannelsCell NucleusEnergy MetabolismMeiosisMiceMitochondriaOocytesPhosphorylationAMP-Activated Protein KinasesCalcium Channelsmitochondrial calcium uniporterAMPKmeiosismitochondrial Ca2+mitochondrial functionoocytes

Identifiers

PMID34546582
PMCPMC8560604
OpenAlexW3200601114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.