Evidence map›Paper›PMID 34546536›Full record

ArticleChinese journal of integrative medicine2022

Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling.

Bo-Ra Jeon, Muhammad Irfan, Seung Eun Lee, Jeong Hoon Lee, Man Hee Rhee

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Article in Chinese journal of integrative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bo-Ra JeonLaboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
Muhammad IrfanLaboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea.
Seung Eun LeeDepartment of Herbal Crop Research, National Institute of Horticultural and Herbal Science (NIHHS), Eumseong, 27709, Republic of Korea.
Jeong Hoon LeeDepartment of Herbal Crop Research, National Institute of Horticultural and Herbal Science (NIHHS), Eumseong, 27709, Republic of Korea.
Man Hee RheeLaboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu, 41566, Republic of Korea. rheemh@knu.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the antiplatelet and antithrombotic activity of Rumex acetosella extract.

methodsStandard light aggregometry was used for platelet aggregation, intracellular calcium mobilization assessed using Fura-2/AM, granule secretion (ATP release) by luminometer, and fibrinogen binding to integrin α

resultsRumex acetosella displayed the ability to inhibit platelet aggregation, calcium mobilization, granule secretion, and fibrinogen binding to integrin α

conclusionRumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling, and it may protect against the development of platelet-related cardiovascular diseases.

Indexed as

Phosphatidylinositol 3-KinasesRumexBlood PlateletsCalciumFibrinogenMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasePhosphorylationPlant ExtractsPlatelet AggregationPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktCalciumFibrinogenMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesPlant ExtractsPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexProto-Oncogene Proteins c-aktantiplateletethnomedicineintegrin α IIb β 3mitogen-activated protein kinaseRumex acetosella L

Identifiers

PMID34546536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.