Evidence map›Paper›PMID 34546511›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Association of cholesterol 7α-hydroxylase (CYP7A1) promoter polymorphism (rs3808607) and cholesterol 24S-hydroxylase (CYP46A1) intron 2 polymorphism (rs754203) with serum lipids, vitamin D levels, and multiple sclerosis risk in the Turkish population.

Eda Sezer, Birsen Can Demirdöğen, Şeref Demirkaya, Giray Bulut, Merve Akkulak, Emre Evin, Orhan Adalı

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eda SezerDepartment of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-4052-1666
Birsen Can DemirdöğenDepartment of Biomedical Engineering, TOBB University of Economics and Technology, Ankara, Turkey. bcandemirdogen@etu.edu.tr.ORCID http://orcid.org/0000-0002-1536-6123
Şeref DemirkayaDepartment of Neurology, University of Health Sciences, Gülhane Health Sciences Institute, Ankara, Turkey.
Giray BulutDepartment of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-0986-1144
Merve AkkulakDepartment of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2834-7682
Emre EvinDepartment of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0002-5805-7419
Orhan AdalıDepartment of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.ORCID http://orcid.org/0000-0001-8484-1146
Middle East Technical University · TRSağlık Bilimleri Üniversitesi · TRTOBB University of Economics and Technology · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with multiple sclerosis (MS) have significantly lower vitamin D levels. Cholesterol is known to be the precursor for vitamin D synthesis, and cholesterol removal is regulated by cholesterol 7α-hydroxylase (CYP7A1) in the liver and cholesterol 24S-hydroxylase (CYP46A1) in the brain. In this study, single nucleotide polymorphisms (SNPs) within the genes CYP7A1 (rs3808607) and CYP46A1 (rs754203) were investigated for their effects on serum lipid profiles, vitamin D levels, and the risk of developing MS.

methodsPatients with MS (n = 191) and controls (n = 100) were tested using the PCR-RFLP method to determine their genotypes for rs3808607 and rs754203 SNPs.

resultsThe minor (C) allele frequency for CYP7A1 rs3808607 variation was 0.380 in patients with MS and 0.305 in control subjects (P = .074). For CYP46A1 rs754203, the frequencies of the minor (C) allele were 0.272 and 0.250 in patients and control subjects, respectively (P = .563). Serum vitamin D (25(OH)D3) concentrations were significantly lower in patients than in control subjects (P = .002). The CYP46A1 rs754203 SNP was associated with total cholesterol levels in patients, whereas the CYP7A1 rs3808607 variant was not associated with serum lipid parameters or vitamin D levels in patients or control subjects.

conclusionCYP7A1 rs3808607 and CYP46A1 rs754203 variations are not likely to confer an independent risk for MS development in the Turkish population. To the best of our knowledge, this is the first study to investigate the association between CYP46A1 rs754203 and MS risk.

Indexed as

Cholesterol 24-HydroxylaseCholesterol 7-alpha-HydroxylaseMultiple SclerosisCholesterolHumansIntronsLipidsPolymorphism, Single NucleotidePromoter Regions, GeneticTurkeyVitamin DCholesterolCholesterol 24-HydroxylaseCholesterol 7-alpha-HydroxylaseCYP7A1 protein, humanLipidsVitamin DCholesterolCYP46A1CYP7A1Multiple sclerosisSNPVitamin D

Identifiers

PMID34546511
OpenAlexW3201374713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.