Evidence map›Paper›PMID 34546440›Full record

ArticleParasitology research2021

First time identification of subconjunctival Dirofilaria immitis in Turkey: giant episcleral granuloma mimicking scleritis.

Mehmet Aykur, Ayşe Yağcı, Sami Simşek, Melis Palamar, Banu Yaman, Metin Korkmaz, Hande Dagci

Abstract readCase Reports
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In one paragraph

Article in Parasitology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Autochthonous human subconjunctival dirofilariasis in europe: a case report from Italy and literature review.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  3. Review
  4. Circulation ofLife (Basel, Switzerland) · 2025
    Article
  5. A meta-analysis onParasitology · 2025
    Review
  6. Article
  7. International journal for parasitology. Parasites and wildlife · 2024
    Article
  8. Current State of CanineAnimals : an open access journal from MDPI · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mehmet AykurDepartment of Parasitology, Faculty of Medicine, University of Tokat Gaziosmanpasa, Tokat, Turkey. mehmetaykur@gmail.com.ORCID http://orcid.org/0000-0002-6100-1037
Ayşe YağcıDepartment of Ophthalmology, Faculty of Medicine, University of Ege, Izmir, Turkey.
Sami SimşekDepartment of Parasitology, Faculty of Veterinary Medicine, University of Fırat, Elazig, Turkey.
Melis PalamarDepartment of Ophthalmology, Faculty of Medicine, University of Ege, Izmir, Turkey.
Banu YamanDepartment of Pathology Department, Faculty of Medicine, University of Ege, Izmir, Turkey.
Metin KorkmazDepartment of Parasitology, Faculty of Medicine, University of Ege, Izmir, Turkey.
Hande DagciDepartment of Parasitology, Faculty of Medicine, University of Ege, Izmir, Turkey.
Ege University · TRFırat University · TRTokat Gaziosmanpaşa Üniversitesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dirofilariasis is a vector-borne disease that is present worldwide. This report describes a giant subconjunctival granuloma which mimics scleritis, caused by D. immitis. A 60-year-old man was referred with the complaints of irritation, redness, and swelling at the medial part of the right eye. He was living in Izmir province located in western Turkey. Slit-lamp examination showed a firm, immobile mass measuring 13.0 × 5.0 × 5.0 mm with yellowish creamy color. The mass was completely removed surgically under local anesthesia mainly for diagnosis. Histopathology revealed typical morphological features of a filarioid nematode in favor of Dirofilaria as characterized by the external smooth cuticular surface, cuticular layer, muscle layer, and intestinal tubule. Molecular study was performed using DNA isolated from paraffin-embedded tissue sections of the worm. PCR amplification and then DNA sequence analysis of cytochrome c oxidase subunit 1 (cox1) gene fragment confirmed that the worm was D. immitis. It is suggested that this may represent the first human case of D. immitis occurring in subconjunctival granuloma in Turkey. Although rare, D. immitis caused by ocular dirofilariasis in humans should be considered.

Indexed as

Dirofilaria immitisDirofilariasisAnimalsGranulomaHumansMaleMiddle AgedScleritisTurkeyDirofilaria immitisHumanMitochondrial DNA analysisSubconjunctivaTurkey

Identifiers

PMID34546440
OpenAlexW3199331677

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.