Evidence map›Paper›PMID 34546414›Full record

ArticleThe Journal of membrane biology2022

In Vitro Selection of Short DNA Aptamers that Can Inhibit or Alleviate Cocaine and MK-801 Inhibition of Muscle-Type Nicotinic Acetylcholine Receptors.

Kannan Sivaprakasam, George P Hess

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of membrane biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Kannan SivaprakasamDepartment of Molecular Biology and Genetics, Cornell University, 216 Biotechnology Building, Ithaca, NY, 14853-2703, USA. ksivaprakasam@stcloudstate.edu.ORCID 0000-0003-0555-7855
George P HessDepartment of Molecular Biology and Genetics, Cornell University, 216 Biotechnology Building, Ithaca, NY, 14853-2703, USA.
Cornell University · USSt. Cloud State University · US

Funding

NIH HHS NS08527
6 · The paper itself

Abstract

Ligands of high specificity and selectivity have been selected for biological molecules of interest including nicotinic acetylcholine receptor (nAChR) using combinatorial libraries of nucleic acids. The nAChR belongs to a group of structurally related proteins that regulate signal transmission between ~ 10

Indexed as

Aptamers, NucleotideCocaineReceptors, NicotinicAnimalsCell LineDizocilpine MaleateMammalsMusclesAptamers, NucleotideCocaineDizocilpine MaleateReceptors, NicotinicNicotinic acetylcholine receptor (nAChR)Patch clamp techniqueRibonucleic acid (RNA)

Identifiers

PMID34546414
OpenAlexW3201632271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.