Evidence map›Paper›PMID 34546409›Full record

ArticleAnnals of hematology2022

Total body irradiation-containing conditioning regimens without antithymocyte globulin in adults with aplastic anemia undergoing umbilical cord blood transplantation.

Nobuhiro Hiramoto, Hirohito Yamazaki, Yukinori Nakamura, Naoyuki Uchida, Makoto Murata, Tadakazu Kondo, Satoshi Yoshioka, Tetsuya Eto, Akinori Nishikawa, Takafumi Kimura and 6 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Annals of hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07078721 (Efficacy and Safety Study of Umbilical Cord Blood Transplantation), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07078721 phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy and Safety Study of Umbilical Cord Blood Transplantation (UCBT) With Total Marrow Irradiation (TMI)-Based Conditioning Regimen for Adults With Refractory/Relapsed Aplastic Anemia (AA).

TypeinterventionalSponsorInstitute of Hematology & Blood Diseases Hospital, ChinaRan2025 to 2028Enrolled11ConditionsAplastic Anemia IdiopathicArmsTotal Marrow Irradiation, Fludarabine (FLU), Melphalan (Mel)
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 14 institutions in 1 country.

Nobuhiro HiramotoDepartment of Hematology, Kobe City Medical Center General Hospital, 2-2-1, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan. kvlqt1789@gmail.com.ORCID http://orcid.org/0000-0002-0472-6680
Hirohito YamazakiDivision of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan.
Yukinori NakamuraThird Department of Internal Medicine, Yamaguchi University School of Medicine, Ube, Japan.
Naoyuki UchidaDepartment of Hematology, Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital, Tokyo, Japan.
Makoto MurataDepartment of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tadakazu KondoDepartment of Hematology and Oncology, Kyoto University Hospital, Kyoto, Japan.
Satoshi YoshiokaDepartment of Hematology, Kobe City Medical Center General Hospital, 2-2-1, Minatojima-Minamimachi, Chuo-ku, Kobe, 650-0047, Japan.
Tetsuya EtoDepartment of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
Akinori NishikawaDepartment of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan.
Takafumi KimuraJapanese Red Cross Kinki Block Blood Center, Osaka, Japan.
Tatsuo IchinoheDepartment of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.
Yoshiko AtsutaJapanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
Yasushi OnishiDepartment of Hematology and Rheumatology, Tohoku University Hospital, Miyagi, Japan.
Ritsuro SuzukiDepartment of Oncology and Hematology, Shimane University Hospital, Izumo, Japan.
Takehiko MoriDivision of Hematology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Adult Aplastic Anemia Working Group of the Japanese Society for Hematopoietic Cell Transplantation
Kobe City Medical Center General Hospital · JPHamanomachi Hospital · JPHiroshima University · JPJapanese Red Cross Society, Japan · JPKanazawa University Hospital · JPKeio University · JPKyoto University Hospital · JPNagoya University · JPShimane University Hospital · JPThe Japanese Data Center for Hematopoietic Cell Transplantation · JPTohoku University Hospital · JPToranomon Hospital · JPWakayama Medical University · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thus far, there have been no large cohort studies on total body irradiation (TBI)-containing conditioning regimens without antithymocyte globulin (ATG) in adults with aplastic anemia (AA) undergoing umbilical cord blood (UCB) transplantation (UCBT). We retrospectively analyzed 115 adults with idiopathic AA undergoing UCBT using TBI-containing reduced-intensity conditioning (RIC) regimens without ATG between 2000 and 2018 on behalf of the Adult Aplastic Anemia Working Group of the Japanese Society for Hematopoietic Cell Transplantation. We then compared transplantation outcomes between a fludarabine (Flu)- and melphalan (Mel)-based regimen (FM) and a Flu- and cyclophosphamide (Cy)-based regimen (FC). The median patient age at UCBT was 41 years. The median total nucleated cell and total CD34

Indexed as

AdolescentAdultAgedAnemia, AplasticAntilymphocyte SerumFemaleFetal BloodGraft vs Host DiseaseHumansMaleMiddle AgedRetrospective StudiesTransplantation ConditioningTreatment OutcomeWhole-Body IrradiationYoung AdultAntilymphocyte SerumAntithymocyte globulinAplastic anemiaCord blood transplantationTotal body irradiation

Identifiers

PMID34546409
OpenAlexW3201248378

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.