Evidence map›Paper›PMID 34545985›Full record

ArticleChembiochem : a European journal of chemical biology2021

Protein Design with Fluoroprolines: 4,4-Difluoroproline Does Not Eliminate the Rate-Limiting Step of Thioredoxin Folding.

Jennie O' Loughlin, Silvia Napolitano, Marina Rubini

Open access · hybridAbstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jennie O' LoughlinSchool of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.ORCID 0000-0003-3336-0320
Silvia NapolitanoDepartment of Molecular Biology and Biophysics, ETH Zürich, Otto-Stern-Weg 5, 8093, Zürich, Switzerland.ORCID 0000-0001-9020-0767
Marina RubiniSchool of Chemistry, University College Dublin, Belfield, Dublin 4, Ireland.ORCID 0000-0002-3102-2558
University College Dublin · IEETH Zurich · CH

Funding

UCD School of Chemistry (SF1888
6 · The paper itself

Abstract

C

Indexed as

HumansProlineProtein FoldingThermodynamicsThioredoxins4,4-difluoroprolinefluoro-prolineProlineThioredoxins4,4-difluoroprolineprotein designprotein foldingprotein stabilitythioredoxin fold

Identifiers

PMID34545985
PMCPMC9292674
OpenAlexW3199422238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.