Evidence map›Paper›PMID 34545921›Full record

ArticleThe journal of nutrition, health & aging2021

Intrinsic Capacity as a Determinant of Physical Resilience in Older Adults.

J K Chhetri, Q-L Xue, L Ma, P Chan, R Varadhan

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of nutrition, health & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05891782 (Effects of a HAPA-based Multicomponent Fall Intervention on Older Adults With Declines in Intrinsic Capacity in Nursing Homes), which is not on this map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05891782 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of a HAPA-based Multicomponent Fall Intervention on Older Adults With Declines in Intrinsic Capacity in Nursing Homes

TypeinterventionalSponsorZHANG Qing-huaRan2023 to 2024Enrolled100ConditionsFall RiskArmsHAPA-based Multidomain Fall Risk Management, Regular health education lectures
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  8. Association between intrinsic capacity and dementia risk in older Mexicans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J K ChhetriDr. Jagadish K. Chhetri M.D, Xuanwu Hospital of Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. E-mail: chhetri_jk@hotmail.com, Twitter: @JagadishChhetri; Dr. Ravi Varadhan Phd, PhD, Johns Hopkins School of Medicine, 550 N. Broadway, Suite 1103-A, Baltimore, MD 21205, USA, E-mail: ravi.varadhan@jhu.edu, Twitter: @Tyche63.
Q-L Xue
L Ma
P Chan
R Varadhan

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
ConProject-001UH3AG056933 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J., VARADHAN, RAVI · 2019 to 2021
$7.0M
Characterizing Resiliencies to Physical Stressors in Older Adults: A Dynamical Physiological Systems ApproachUH2AG056933 · NIA · JOHNS HOPKINS UNIVERSITY · PI BANDEEN-ROCHE, KAREN J., VARADHAN, RAVI · 2017 to 2018
$3.5M
NIA NIH HHS P30 AG021334NIA NIH HHS UH2 AG056933NIA NIH HHS UH3 AG056933
6 · The paper itself

Abstract

The traditional disease-oriented model of healthcare is inadequate to address the needs of the older population. Greater attention should be given to strategies that promote healthy aging. Recently proposed constructs of intrinsic capacity (IC) and physical resilience (PR) hold great potential to reshape geriatric medicine and aging research. These constructs accentuate the positive health attributes of older people in contrast to the popular frailty construct that is centered on functional deficits. IC was introduced by the World Health Organization (WHO) as a composite of all the physical and mental capacities. WHO has emphasized enhancement of IC throughout the life course so as to maintain functional ability in old age. PR, recently highlighted by the National Institute on Aging, is the ability to successfully cope with stressors. High levels of resilience can result in desirable clinical and functional outcomes after stressors. Therefore, it is important to understand the underlying physiology of PR and the risk factors contributing to diminished PR. The main goal of this article is to explore the potential relationship between IC and PR. Based on a classical theory of aging, we postulate that IC is a determinant of PR and is also a high-level integrative measure of physiologic reserve which is the fundamental factor underlying one's ability to withstand stressors. A major implication of our postulates is that even though IC is only one of the many determinants of PR, it could serve as an important intervenable target for enhancing resilience in older adults.

Indexed as

FrailtyHealthy AgingActivities of Daily LivingAdaptation, PsychologicalAgedAgingHumansagingfrailtyintegrated carephysiologic reserveResilience

Identifiers

PMID34545921
PMCPMC8035602

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.