Evidence map›Paper›PMID 34545791›Full record

ArticleEmerging infectious diseases2021

Therapeutic Efficacy of Human Monoclonal Antibodies against Andes Virus Infection in Syrian Hamsters.

Brandi N Williamson, Joseph Prescott, Jose L Garrido, Raymond A Alvarez, Heinz Feldmann, Maria I Barría

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Brandi N Williamson
Joseph Prescott
Jose L Garrido
Raymond A Alvarez
Heinz Feldmann
Maria I Barría
University of Concepción · CLNational Institute of Allergy and Infectious Diseases · USNational Institutes of Health · USSan Sebastián University · CL

Funding

Development of broadly neutralizing antibodies to treat hantavirus infectionsR43AI138740 · NIAID · ICHOR BIOLOGICS, LLC · PI ALVAREZ, RAYMOND · 2019 to 2020
$355k
NIAID NIH HHS R43 AI138740
6 · The paper itself

Abstract

Andes virus, an orthohantavirus endemic to South America, causes severe hantavirus cardiopulmonary syndrome associated with human-to-human transmission. No approved treatments or vaccines against this virus are available. We show that a combined treatment with 2 monoclonal antibodies protected Syrian hamsters when administered at midstage or late-stage disease.

Indexed as

Hantavirus InfectionsOrthohantavirusAnimalsAntibodies, MonoclonalCricetinaeHumansMesocricetusSouth AmericaAntibodies, MonoclonalAndes orthohantavirusrecombinant human monoclonal antibodiesSyrian hamsterviruseszoonoses

Identifiers

PMID34545791
PMCPMC8462347
OpenAlexW3200067671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.