Evidence map›Paper›PMID 34545696›Full record

Trial reportJournal of cachexia, sarcopenia and muscle2021

Prospective trial to evaluate the prognostic value of different nutritional assessment scores for survival in pancreatic ductal adenocarcinoma (NURIMAS Pancreas SURVIVAL).

Max Heckler, Ulla Klaiber, Felix J Hüttner, Sebastian Haller, Thomas Hank, Henrik Nienhüser, Philip Knebel, Markus K Diener, Thilo Hackert, Markus W Büchler and 1 more

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Max HecklerDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-3213-5068
Ulla KlaiberDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Felix J HüttnerDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Sebastian HallerDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Thomas HankDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Henrik NienhüserDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Philip KnebelDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Markus K DienerDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Thilo HackertDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Markus W BüchlerDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Pascal ProbstDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalnutrition is associated with poor survival in pancreatic cancer patients. Nutritional scores show great heterogeneity diagnosing malnutrition. The aim of this study was to find the score best suitable to identify patients with malnutrition related to worse survival after surgery for pancreatic ductal adenocarcinoma (PDAC). This study represents a follow-up study to the prospective NURIMAS Pancreas trial that evaluated short term impact of nutritional score results after surgery.

methodsRisk of malnutrition was evaluated preoperatively using 12 nutritional assessment scores. Patients were followed-up prospectively for at least 3 years. Patients at risk for malnutrition were compared with those not at risk according to each score using Kaplan-Meier survival statistics.

resultsA total of 116 patients receiving a PDAC resection in curative intent were included. Malnutrition according to the Subjective Global Assessment score (SGA), the Short Nutritional Assessment Questionnaire (SNAQ), and the INSYST2 score was associated with worse overall survival (SGA: at-risk: 392 days; not at-risk: 942 days; P = 0.001; SNAQ: at-risk: 508 days; not at-risk: 971 days; P = 0.027; INSYST2: at-risk: 538 days; not at risk: 1068; P = 0.049). In the multivariate analysis, SGA (hazard ratio of death 2.16, 95% confidence interval 1.34-3.47, P = 0.002) was associated with worse overall survival.

conclusionsMalnutrition as defined by the Subjective Global Assessment is independently associated with worse survival in resected PDAC patients. The SGA should be used to stratify PDAC patients in clinical studies. Severely malnourished patients according to the SGA profit from intensified nutritional therapy should be evaluated in a randomized controlled trial.

Indexed as

Carcinoma, Pancreatic DuctalPancreatic NeoplasmsFollow-Up StudiesHumansNutritional StatusNutrition AssessmentPancreasPrognosisProspective StudiesClinical trialMalnutritionOncologyPancreatic cancerSurgery

Identifiers

PMID34545696
PMCPMC8718045
OpenAlexW3199406487

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.