Evidence map›Paper›PMID 34545638›Full record

ArticleJournal of clinical laboratory analysis2021

Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis.

Ramtin Omid-Shafaat, Hassan Moayeri, Karim Rahimi, Mohammad-Nazir Menbari, Zakaria Vahabzadeh, Mohammad-Saied Hakhamaneshi, Bijan Nouri, Bayazid Ghaderi, Mohammad Abdi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05771337 (Circular RNA and Chemerin in Blood of Breast Cancer Patients), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05771337 unknown statusnot on this mapstarted 2023, after this paper: background citation

Circular RNA and Chemerin in Blood of Breast Cancer Patients

TypeobservationalSponsorAssiut UniversityRan2023 to 2025Enrolled80ConditionsBreast CancerArmsblood sample
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ramtin Omid-ShafaatStudent Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Hassan MoayeriDepartment of Surgery, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Karim RahimiDepartment of Molecular Biology and Genetics, Gene Expression and Gene Medicine, Aarhus University, Aarhus, Denmark.
Mohammad-Nazir MenbariCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Zakaria VahabzadehDepartment of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohammad-Saied HakhamaneshiDepartment of Clinical Biochemistry, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Bijan NouriDepartment of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Bayazid GhaderiCancer and Immunology Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohammad AbdiCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.ORCID https://orcid.org/0000-0002-4766-0423
Kurdistan University of Medical Sciences · IRAarhus University · DK

Funding

Kurdistan University Of Medical Sciences IR.MUK.REC.1398.170
6 · The paper itself

Abstract

backgroundRecently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ-ELP3 and Circ-FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.

methodsSeventy-eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined.

resultsCompared to non-cancerous controls, Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ-ELP3 and Circ-FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ-ELP3 and Circ-FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively.

conclusionBriefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.

Indexed as

AdultBiomarkers, TumorBreast NeoplasmsFemaleHumansMiddle AgedRNA, CircularROC CurveBiomarkers, TumorRNA, Circularbreast cancercancer biomarkerCirc-ELP3Circ-FAF1diagnostic efficiency

Identifiers

PMID34545638
PMCPMC8605127
OpenAlexW3199831375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.