Evidence map›Paper›PMID 34545397›Full record

ArticleEuropean heart journal2021

Cardiovascular magnetic resonance imaging in suspected cardiac tumour: a multicentre outcomes study.

Chetan Shenoy, John D Grizzard, Dipan J Shah, Mahwash Kassi, Michael J Reardon, Marianna Zagurovskaya, Han W Kim, Michele A Parker, Raymond J Kim

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in European heart journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
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  7. Excessive left ventricular trabeculations mimicking a thrombus.European heart journal. Case reports · 2025
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  19. Case Report: A rare diffuse mitral valvular myxoma.Frontiers in cardiovascular medicine · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Chetan ShenoyUniversity of Minnesota Medical Center, Cardiovascular Division, Department of Medicine, 420 Delaware St MMC 508, Minneapolis, MN, USA.ORCID 0000-0001-8877-4999
John D GrizzardVirginia Commonwealth University Medical Center, 1250 E. Marshall Street, Richmond, VA, USA.
Dipan J ShahHouston Methodist Hospital, 6550 Fannin St Suite 1901, Houston, TX, USA.ORCID 0000-0002-6179-2393
Mahwash KassiHouston Methodist Hospital, 6550 Fannin St Suite 1901, Houston, TX, USA.
Michael J ReardonHouston Methodist Hospital, 6550 Fannin St Suite 1901, Houston, TX, USA.
Marianna ZagurovskayaVirginia Commonwealth University Medical Center, 1250 E. Marshall Street, Richmond, VA, USA.
Han W KimDuke University Medical Center, Duke Medical Pavilion, 10 Medicine Circle, Rm IE-58 Durham, NC 27710, USA.
Michele A ParkerDuke University Medical Center, Duke Medical Pavilion, 10 Medicine Circle, Rm IE-58 Durham, NC 27710, USA.ORCID 0000-0001-8646-4823
Raymond J KimDuke University Medical Center, Duke Medical Pavilion, 10 Medicine Circle, Rm IE-58 Durham, NC 27710, USA.
Duke Medical Center · USHouston Methodist · USVirginia Commonwealth University Medical Center · USUniversity of Minnesota Medical Center · US

Funding

Delayed-Enhancement Cardiac MRI: Prognostic Implications and Improved ImagingR01HL064726 · NHLBI · NORTHWESTERN UNIVERSITY · PI KIM, RAYMOND J · 2001 to 2014
$4.1M
Cardiac Fibrosis and Risk Prediction in Cancer Treatment-Related CardiotoxicityK23HL132011 · NHLBI · UNIVERSITY OF MINNESOTA · PI SHENOY, CHETAN N · 2016 to 2020
$884k
NHLBI NIH HHS K23 HL132011NHLBI NIH HHS R01 HL064726
6 · The paper itself

Abstract

aimsCardiovascular magnetic resonance (CMR) imaging is a key diagnostic tool for the evaluation of patients with suspected cardiac tumours. Patient management is guided by the CMR diagnosis, including no further testing if a mass is excluded or if only a pseudomass is found. However, there are no outcomes studies validating this approach. METHODS AND

resultsIn this multicentre study of patients undergoing clinical CMR for suspected cardiac tumour, CMR diagnoses were assigned as no mass, pseudomass, thrombus, benign tumour, or malignant tumour. A final diagnosis was determined after follow-up using all available data. The primary endpoint was all-cause mortality. Among 903 patients, the CMR diagnosis was no mass in 25%, pseudomass in 16%, thrombus in 16%, benign tumour in 17%, and malignant tumour in 23%. Over a median of 4.9 years, 376 patients died. Compared with the final diagnosis, the CMR diagnosis was accurate in 98.4% of patients. Patients with CMR diagnoses of pseudomass and benign tumour had similar mortality to those with no mass, whereas those with malignant tumour [hazard ratio (HR) 3.31 (2.40-4.57)] and thrombus [HR 1.46 (1.00-2.11)] had greater mortality. The CMR diagnosis provided incremental prognostic value over clinical factors including left ventricular ejection fraction, coronary artery disease, and history of extracardiac malignancy (P < 0.001).

conclusionIn patients with suspected cardiac tumour, CMR has high diagnostic accuracy. Patients with CMR diagnoses of no mass, pseudomass, and benign tumour have similar long-term mortality. The CMR diagnosis is a powerful independent predictor of mortality incremental to clinical risk factors.

Indexed as

Heart NeoplasmsMagnetic Resonance Imaging, CineHumansMagnetic Resonance ImagingPredictive Value of TestsPrognosisRisk AssessmentStroke VolumeVentricular Function, LeftCardiac magnetic resonanceCardiac massesCardiac tumoursCardio-oncologyDiagnosisPrognosis

Identifiers

PMID34545397
PMCPMC8720142
OpenAlexW3199962346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.