ArticleiScience2021
The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells.
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Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
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Who cites it
41 citing papers in PubMed, 58 citations in OpenAlex.
- Biological Rhythms in Coronavirus Pneumonia Pathogenesis.Journal of biological rhythms · 2026Article
- Circadian Rhythms in Acute Respiratory Distress Syndrome: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Adrenaline restores Bmal1 transcriptional rhythms dampened by SARS-CoV-2 infection in Cthrc1-positive pulmonary fibroblasts derived from the Nile grass rat.Scientific reports · 2026Article
- Chronobiology of neurotropic viruses: rhythmic viral entry and arrhythmic host clocks.Cell discovery · 2026Article
- Mechanisms of Cell-Cell Fusion in SARS-CoV-2: An Evolving Strategy for Transmission and Immune Evasion.Viruses · 2025Review
- Circadian clock proteins BMAL1 and CLOCK regulate HSV-1 entry into nerve cells through NECTIN-1.Virology journal · 2025Article
- Dual-approach co-expression analysis framework (D-CAF) enables identification of novel circadian co-regulation from multi-omic timeseries data.BMC bioinformatics · 2025Article
- A theoretical systems chronopharmacology approach for COVID-19: Modeling circadian regulation of lung infection and potential precision therapies.CPT: pharmacometrics & systems pharmacology · 2025Article
- Chronic CRYPTOCHROME deficiency enhances cell-intrinsic antiviral defences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Basic helix-loop-helix ARNT like 1 regulates the function of immune cells and participates in the development of immune-related diseases.Burns & trauma · 2025Review
- Alterations in Circadian Rhythms, Sleep, and Physical Activity in COVID-19: Mechanisms, Interventions, and Lessons for the Future.Molecular neurobiology · 2024Review
- Dual-Approach Co-expression Analysis Framework (D-CAF) Enables Identification of Novel Circadian Regulation From Multi-Omic Timeseries Data.bioRxiv : the preprint server for biology · 2024Article
- Impact of Vaccination Time on Anti-SARS-CoV-2 Antibody Levels in Adults: A Quasi-experimental Study.Cureus · 2024Article
- Crosstalk between circadian clocks and pathogen niche.PLoS pathogens · 2024Review
- Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration.Molecular neurodegeneration · 2024Review
- Article
- Chikungunya Virus, Metabolism, and Circadian Rhythmicity Interplay in Phagocytic Cells.Metabolites · 2023Review
- Cognitive Impairment in Multiple Sclerosis.Bioengineering (Basel, Switzerland) · 2023Review
- The multiple roles of salt-inducible kinases in regulating physiology.Physiological reviews · 2023Review
- Biological rhythms in COVID-19 vaccine effectiveness in an observational cohort study of 1.5 million patients.The Journal of clinical investigation · 2023Observational
Corrections and comments
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Authors and funding
28 authors at 8 institutions in 5 countries.
Xiaodong ZhuangNuffield Department of Medicine, University of Oxford, Oxford, UK.
Senko TsukudaNuffield Department of Medicine, University of Oxford, Oxford, UK.
Florian WrenschUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Peter A C WingNuffield Department of Medicine, University of Oxford, Oxford, UK.
Mirjam SchillingNuffield Department of Medicine, University of Oxford, Oxford, UK.
James M HarrisNuffield Department of Medicine, University of Oxford, Oxford, UK.
Helene BorrmannNuffield Department of Medicine, University of Oxford, Oxford, UK.
Sophie B MorganRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.
Jennifer L CaneRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.
Laurent MaillyUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Nazia ThakurThe Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.
Carina ConceicaoThe Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.
Harshmeena SanghaniNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Laura HeydmannUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Charlotte BachUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Anna AshtonDepartment of Pharmacology, University of Oxford, Oxford, UK.
Steven WalshDepartment of Pharmacology, University of Oxford, Oxford, UK.
Tiong Kit TanMRC Human Immunology Unit, MRC Weatherall Institute, John Radcliffe Hospital, Oxford 17 OX3 9DS, UK.
Lisa SchimanskiChinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Kuan-Ying A HuangResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung University and Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Catherine SchusterUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Koichi WatashiDepartment of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Timothy S C HinksRespiratory Medicine Unit and National Institute for Health Research Oxford Biomedical Research Centre, Nuffield Department of Medicine, Experimental Medicine, University of Oxford, UK.
Aarti JagannathNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Sridhar R VausdevanDepartment of Pharmacology, University of Oxford, Oxford, UK.
Dalan BaileyThe Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, UK.
Thomas F BaumertUniversité de Strasbourg, Strasbourg, France and INSERM, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France.
Jane A McKeatingNuffield Department of Medicine, University of Oxford, Oxford, UK.
University of Oxford · GBInserm · FRChinese Academy of Medical Sciences & Peking Union Medical College · CNNational Institute for Health Research · GBThe Pirbright Institute · GBChang Gung University · TWJohn Radcliffe Hospital · GBTokyo University of Science · JP
Funding
Biotechnology and Biological Sciences Research Council BBS/E/I/00007034Biotechnology and Biological Sciences Research Council BBS/E/I/COV07001Medical Research Council MR/R022011/1Wellcome Trust 200838/Z/16/ZWellcome Trust 211050/Z/18/Z
Abstract
The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health. SARS-CoV-2 primarily infects cells of the respiratory tract via spike glycoprotein binding to angiotensin-converting enzyme (ACE2). Circadian rhythms coordinate an organism's response to its environment and can regulate host susceptibility to virus infection. We demonstrate that silencing the circadian regulator
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.