Evidence map›Paper›PMID 34545331›Full record

ArticleBioMed research international2021

Xiaoyu Xiezhuo Drink Protects against Ischemia-Reperfusion Acute Kidney Injury in Aged Mice through Inhibiting the TGF-

Qingqing Ye, Hongbo Chen, Hongzhen Ma, Xiaojun Xiang, Shouci Hu, Cong Xia, Lanjun Fu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qingqing YeDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.ORCID https://orcid.org/0000-0002-4440-9575
Hongbo ChenDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Hongzhen MaDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Xiaojun XiangDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Shouci HuDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Cong XiaDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.
Lanjun FuDepartment of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang, China.ORCID https://orcid.org/0000-0002-0392-145X
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is responsible for significant mortality among hospitalized patients that is especially troubling aged people. An effective self-made Chinese medicine formula, Xiaoyu Xiezhuo Drink (XXD), displayed therapeutic effects on AKI. However, the compositions and underlying mechanisms of XXD remain to be elucidated. In this study, we used the ultra-high-performance liquid chromatography method coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) to investigate the chemical components in XXD. Then, the absorbable components of XXD were identified based on the five principles and inputted into the SwissTargetPrediction and STITCH databases to identify the drug targets. AKI-related targets were collected from the GenCLiP 3, GeneCards, and DisGeNET databases. The crossover genes of XXD and AKI were identified for functional enrichment analysis. The protein-protein interaction (PPI) network of crossover genes was constructed, followed by the identification of hub genes. Subsequently, the effects and potential mechanisms of XXD on AKI predicted by the network pharmacology and bioinformatics analyses were experimentally validated in ischemia-reperfusion (I/R) injury-induced AKI aged mouse models. A total of 122 components in XXD were obtained; among them, 58 components were found that could be absorbed in the blood. There were 800 potential drug targets predicted from the 58 absorbable components in AKI which shared 36 crossover genes with AKI-related targets. The results of functional enrichment analysis indicated that crossover genes mostly associated with the response to oxidative stress and the HIF1 signaling pathway. In the PPI network analysis, 12 hub genes were identified, including ALB, IL-6, TNF, TP53, VEGFA, PTGS2, TLR4, NOS3, EGFR, PPARG, HIF1A, and HMOX1. In AKI aged mice, XXD prominently alleviated I/R injury-induced renal dysfunction, abnormal renal pathological changes, and cellular senescence, inflammation, and oxidative damage with a reduction in the expression level of the inflammatory mediator,

Indexed as

Acute Kidney InjuryAnimalsChinaChromatography, High Pressure LiquidDisease Models, AnimalDrugs, Chinese HerbalIschemiaKidneyMaleMiceMice, Inbred C57BLProtective AgentsReperfusionReperfusion InjurySignal TransductionTandem Mass SpectrometryDrugs, Chinese HerbalProtective Agentsxiaoyu zhixue

Identifiers

PMID34545331
PMCPMC8449228
OpenAlexW3199980025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.