Evidence map›Paper›PMID 34545298›Full record

ArticleOxidative medicine and cellular longevity2021

Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-

Yi-Ling Wen, Ziyu He, De-Xing Hou, Si Qin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Crocetin: A Systematic Review.Frontiers in pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yi-Ling WenKey Laboratory for Food Science and Biotechnology of Hunan Province, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Ziyu HeThe United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
De-Xing HouThe United Graduate School of Agricultural Sciences, Faculty of Agriculture, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Si QinKey Laboratory for Food Science and Biotechnology of Hunan Province, College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.ORCID https://orcid.org/0000-0002-0788-2099
Kagoshima University · JPHunan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crocetin is a main bioactive component with a carotenoid skeleton in

Indexed as

AnimalsAnti-Inflammatory AgentsBinding SitesCarotenoidsHeme Oxygenase-1JNK Mitogen-Activated Protein KinasesLipopolysaccharidesMacrophagesMAP Kinase Kinase 1MiceMolecular Docking SimulationNF-E2-Related Factor 2NF-kappa BNF-KappaB Inhibitor alphaNitric Oxide Synthase Type IIPhosphorylationAnti-Inflammatory AgentsCarotenoidsHeme Oxygenase-1JNK Mitogen-Activated Protein KinasesLipopolysaccharidesMap2k1 protein, mouseMAP Kinase Kinase 1NF-E2-Related Factor 2NF-kappa BNF-KappaB Inhibitor alphaNitric Oxide Synthase Type IIRNA, Small Interferingtrans-sodium crocetinateVitamin A

Identifiers

PMID34545298
PMCPMC8449229
OpenAlexW3199549000

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.