Evidence map›Paper›PMID 34545109›Full record

ArticleScientific reports2021

A new approach to produce IgG

Caizhi Zhao, Wei Zhang, Guihua Gong, Liping Xie, Ming-Wei Wang, Youjia Hu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Fluorescence-Based Protein Stability Monitoring-A Review.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Caizhi ZhaoSchool of Pharmacy, Fudan University, Shanghai, 201203, China.
Wei ZhangChina State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Guihua GongChina State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Liping XieChina State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Ming-Wei WangSchool of Pharmacy, Fudan University, Shanghai, 201203, China. mwwang@simm.ac.cn.
Youjia HuChina State Institute of Pharmaceutical Industry, Shanghai, 201203, China. huyoujia@sinopharm.com.
Shanghai Institute of Pharmaceutical Industry · CNFudan University · CNNational Center for Drug Screening · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While achieving rapid developments in recent years, bispecific antibodies are still difficult to design and manufacture, due to mispair of both heavy and light chains. Here we report a novel technology to make bispecific molecules. The knob-into-hole method was used to pair two distinct heavy chains as a heterodimer. IgG

Indexed as

Amino Acid SubstitutionAnimalsAntibodies, BispecificAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigens, CDHEK293 CellsHumansImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsIn Vitro TechniquesLymphocyte Activation Gene 3 ProteinMaleModels, MolecularMutagenesis, Site-DirectedAntibodies, BispecificAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedAntigens, CDImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin Light ChainsLymphocyte Activation Gene 3 ProteinPDCD1 protein, humanpembrolizumabProgrammed Cell Death 1 Receptor

Identifiers

PMID34545109
PMCPMC8452627
OpenAlexW3134008442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.