Evidence map›Paper›PMID 34544951›Full record

ArticleInternal medicine (Tokyo, Japan)2022

A Rare Case of Rheumatoid Arthritis with Tocilizumab-induced Intestinal Mucosal Injury.

Akito Ohkubo, Takashi Osoegawa, Naohiko Harada, Yoichiro Iboshi, Yorinobu Sumida, Makoto Nakamuta, Eiichi Suematsu, Hiroyuki Kobayashi, Eikichi Ihara

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Akito OhkuboDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Takashi OsoegawaDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Naohiko HaradaDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Yoichiro IboshiDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Yorinobu SumidaDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Makoto NakamutaDepartment of Gastroenterology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Eiichi SuematsuDepartment of Rheumatology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Japan.
Hiroyuki KobayashiDepartment of Gastroenterology, Fukuoka Sanno Hospital, Japan.
Eikichi IharaDepartment of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
National Kyushu Medical Center · JPKyushu University · JPSanno Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal mucosal injury that develops as a complication of tocilizumab (TCZ) is usually associated with diverticulosis. We herein report a rare case of TCZ-induced intestinal mucosal injury in the absence of diverticulosis. A 74-year-old woman suffering from rheumatoid arthritis started taking TCZ. Six months later, she complained of hematochezia and abdominal pain. Colonoscopy revealed multiple ulcers spreading from the cecum to the transverse colon but no diverticulosis. These lesions were cured at three months after the discontinuation of TCZ. We should consider TCZ as a risk factor for intestinal mucosal injury, even if patients have no history of intestinal disease associated with diverticulosis.

Indexed as

Antirheumatic AgentsArthritis, RheumatoidAgedAntibodies, Monoclonal, HumanizedFemaleHumansTreatment OutcomeAntibodies, Monoclonal, HumanizedAntirheumatic AgentstocilizumabenteritisIL-6rheumatoid arthritistocilizumab

Identifiers

PMID34544951
PMCPMC9038478
OpenAlexW3199485287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.