Evidence map›Paper›PMID 34544866›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

The transcription regulator BrsR serves as a network hub of natural competence protein-protein interactions in

Hua Qin, Zhengzhong Zou, David Anderson, Yu Sang, Dustin Higashi, Jens Kreth, Justin Merritt

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Inhibitory Effect of Adsorption ofInternational journal of molecular sciences · 2023
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hua QinDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0003-4832-9895
Zhengzhong ZouDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-5695-8168
David AndersonDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.
Yu SangDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.
Dustin HigashiDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.
Jens KrethDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239.ORCID 0000-0002-8599-8310
Justin MerrittDepartment of Restorative Dentistry, Oregon Health and Science University, Portland, OR 97239; merrittj@ohsu.edu.ORCID 0000-0002-3464-0490
Oregon Health & Science University · US

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
The LytTR Regulatory Systems of Streptococcus mutansR01DE022083 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI MERRITT, JUSTIN · 2013 to 2016
$1.5M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
$424k
NCI NIH HHS P30 CA069533NEI NIH HHS P30 EY010572NIDCR NIH HHS R01 DE022083NIDCR NIH HHS R01 DE029492NIDCR NIH HHS R21 DE029612NIDCR NIH HHS R35 DE028252NIH HHS S10 OD012246
6 · The paper itself

Abstract

Genome evolution is an essential and stringently regulated aspect of biological fitness. For bacteria, natural competence is one of the principal mechanisms of genome evolution and is frequently subject to multiple layers of regulation derived from a plethora of environmental and physiological stimuli. Here, we present a regulatory mechanism that illustrates how such disparate stimuli can be integrated into the

Indexed as

Gene Expression Regulation, BacterialProtein Interaction MapsBacterial ProteinsBacteriocinsStreptococcus mutansTranscription FactorsBacterial ProteinsBacteriocinsTranscription Factorsbacteriocingene regulationgenetic networksnatural competenceprotein–protein interactions

Identifiers

PMID34544866
PMCPMC8488657
OpenAlexW3199952977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.