ArticleProceedings of the National Academy of Sciences of the United States of America2021
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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27citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 13% of its field
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
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- Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication.Journal of virology · 2023Article
- Antiviral effects of interferon-stimulated genes in bats.Frontiers in cellular and infection microbiology · 2023Review
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- Natural Products-Based Drug Design against SARS-CoV-2 Mpro 3CLpro.International journal of molecular sciences · 2021Article
- Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level.Aging and disease · 2021Article
- SARS-CoV-2 and Zoonotic Preparedness: Unknown Knowns?Infectious microbes & diseases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 8 institutions in 3 countries.
Danielle E AndersonProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
Jin CuiMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Qian YeMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Baoying HuangNational Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
Ya TanMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Chao JiangMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Wenhong ZuMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.ORCID 0000-0001-7864-9342
Jing GongMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China.
Weiqiang LiuKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.
So Young KimDepartment of Molecular Genetics and Microbiology, Duke University, Durham, NC 27708.
Biao Guo YanProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
Kristmundur SigmundssonProgramme in Cardiovascular & Metabolic Disorders, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
Xiao Fang LimProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore.
Fei YeNational Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
Peihua NiuNational Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.
Aaron T IrvingZhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, 310058 Haining, China.ORCID 0000-0002-0196-1570
Haoyu ZhangSchool of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China.ORCID 0000-0003-1468-862X
Yefeng TangSchool of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China.ORCID 0000-0002-6223-0608
Xuming ZhouKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China.ORCID 0000-0002-1100-6294
Yu WangCollege of Life Sciences and Oceanography, Shenzhen University, 518071 Shenzhen, China.
Wenjie TanNational Health Commission Key Laboratory of Biosafety, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China.ORCID 0000-0002-5963-1136
Lin-Fa WangProgramme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School, 169857 Singapore, Singapore; linfa.wang@duke-nus.edu.sg xutan@tsinghua.edu.cn.ORCID 0000-0003-2752-0535
Xu TanMOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Center for Infectious Disease Research, School of Medicine, Tsinghua University, 100084 Beijing, China; linfa.wang@duke-nus.edu.sg xutan@tsinghua.edu.cn.ORCID 0000-0003-4861-4573
Center for Life Sciences · CNNational University of Singapore · SGNational Institute for Viral Disease Control and Prevention · CNChinese Academy of Sciences · CNTsinghua University · CNDuke University · USShenzhen University · CNZhejiang University-University of Edinburgh Institute · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats are responsible for the zoonotic transmission of several major viral diseases, including those leading to the 2003 SARS outbreak and likely the ongoing COVID-19 pandemic. While comparative genomics studies have revealed characteristic adaptations of the bat innate immune system, functional genomic studies are urgently needed to provide a foundation for the molecular dissection of the viral tolerance in bats. Here we report the establishment of genome-wide RNA interference (RNAi) and CRISPR libraries for the screening of the model megabat,
Indexed as
PandemicsAminohydrolasesAnimalsAntiviral AgentsCell LineChiropteraCOVID-19COVID-19 Drug TreatmentFormate-Tetrahydrofolate LigaseHumansMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMultienzyme ComplexesRNA VirusesSARS-CoV-2Virus ReplicationAminohydrolasesAntiviral AgentsFormate-Tetrahydrofolate Ligaseformyl-methenyl-methylenetetrahydrofolate synthetaseMethylenetetrahydrofolate Dehydrogenase (NADP)Minor Histocompatibility AntigensMultienzyme Complexesantiviral therapybatCRISPRRNAi
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