Evidence map›Paper›PMID 34544853›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2021

Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans.

Alexander W Dromerick, Shashwati Geed, Jessica Barth, Kathaleen Brady, Margot L Giannetti, Abigail Mitchell, Matthew A Edwardson, Ming T Tan, Yizhao Zhou, Elissa L Newport and 1 more

3 registry-linked trialsAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 169 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05405140 nacompletednot on this mapstarted 2022, after this paper: background citation

Multiphasic Neuroplasticity Based Training Protocol With Shock Wave Therapy For Post Stroke Spasticity

TypeinterventionalSponsorRiphah International UniversityRan2022 to 2023Enrolled32ConditionsStroke, Spasticity, MuscleArmsShock wave therapy with multiphasic neuroplasticity based training protocol, Conventional physical therapy
NCT05650606 naterminatednot on this mapstarted 2023, after this paper: background citation

Inpatient Rehabilitation and Post-Discharge Outcomes of Patients With Stroke Participating in High Intensity Gait Training

TypeinterventionalSponsorSunnyview Rehabilitation HospitalRan2023 to 2023Enrolled2ConditionsCerebral Vascular AccidentArmsHigh Intensity Gait Training, Conventional Therapy
NCT07661849 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Tele-CPASS, a Telerehabilitation Intervention Using Critical Periods After Stroke Study (CPASS) Compared to In-person CPASS for Upper Extremity Motor Recovery

TypeinterventionalSponsorUniversity of Texas, El PasoRan2025 to 2029Enrolled42ConditionsStroke, Hemiparesis, Upper Extremity Impairments, Stroke RehabilitationArmsTele-CPASS, In-person CPASS therapy
3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  18. Impact of Tai Ji Yunshou with Visual Feedback on Balance and Mobility in Stroke Patients.Medical science monitor : international medical journal of experimental and clinical research · 2025
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Alexander W DromerickResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Shashwati GeedResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Jessica BarthResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Kathaleen BradyResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Margot L GiannettiResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Abigail MitchellResearch Division, MedStar National Rehabilitation Hospital, Washington, DC 20010.
Matthew A EdwardsonCenter for Brain Plasticity and Recovery, Departments of Rehabilitation Medicine and Neurology, Georgetown University Medical Center, Washington, DC 20057.
Ming T TanCenter for Brain Plasticity and Recovery, Departments of Rehabilitation Medicine and Neurology, Georgetown University Medical Center, Washington, DC 20057.
Yizhao ZhouDepartment of Biostatistics, Bioinformatics & Biomathematics, Georgetown University Medical Center, Washington, DC 20057.
Elissa L NewportCenter for Brain Plasticity and Recovery, Departments of Rehabilitation Medicine and Neurology, Georgetown University Medical Center, Washington, DC 20057; eln10@georgetown.edu.ORCID 0000-0002-2783-5062
Dorothy F EdwardsDepartment of Kinesiology, University of Wisconsin-Madison, Madison, WI 53706.

Funding

Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
Neurorehabilitation and Restorative Neuroscience NetworkK12HD093427 · NICHD · GEORGETOWN UNIVERSITY · PI BREGMAN, BARBARA S, DROMERICK, ALEXANDER W · 2017 to 2021
$3.9M
Language and cognition after perinatal strokeR01DC016902 · NIDCD · GEORGETOWN UNIVERSITY · PI GAILLARD, WILLIAM DAVIS, NEWPORT, ELISSA L · 2019 to 2023
$3.0M
Stroke Central Atlantic Network for Research (SCANR)U24NS107222 · NINDS · MEDSTAR HEALTH RESEARCH INSTITUTE · PI Amie Hsia, Peter Ethan Turkeltaub · 2018 to 2026
$2.6M
Training in Plasticity, Development, and Cognitive NeuroscienceT32MH019942 · NIMH · UNIVERSITY OF ROCHESTER · PI NEWPORT, ELISSA L · 1997 to 2011
$2.2M
Language development and linguistic processing after left hemisphere perinatal strokeK18DC014558 · NIDCD · GEORGETOWN UNIVERSITY · PI NEWPORT, ELISSA L · 2015 to 2016
$349k
NCATS NIH HHS KL2 TR001432NICHD NIH HHS K12 HD093427NIDCD NIH HHS K18 DC014558NIDCD NIH HHS R01 DC016902NIMH NIH HHS T32 MH019942NINDS NIH HHS U24 NS107222
6 · The paper itself

Abstract

Restoration of human brain function after injury is a signal challenge for translational neuroscience. Rodent stroke recovery studies identify an optimal or sensitive period for intensive motor training after stroke: near-full recovery is attained if task-specific motor training occurs during this sensitive window. We extended these findings to adult humans with stroke in a randomized controlled trial applying the essential elements of rodent motor training paradigms to humans. Stroke patients were adaptively randomized to begin 20 extra hours of self-selected, task-specific motor therapy at ≤30 d (acute), 2 to 3 mo (subacute), or ≥6 mo (chronic) after stroke, compared with controls receiving standard motor rehabilitation. Upper extremity (UE) impairment assessed by the Action Research Arm Test (ARAT) was measured at up to five time points. The primary outcome measure was ARAT recovery over 1 y after stroke. By 1 y we found significantly increased UE motor function in the subacute group compared with controls (ARAT difference = +6.87 ± 2.63,

Indexed as

Recovery of FunctionAgedCase-Control StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMotor ActivityPrognosisProspective StudiesStrokeStroke Rehabilitationcritical periodneuronal plasticitystrokestroke rehabilitationtime factors

Identifiers

PMID34544853
PMCPMC8488696

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.