Evidence map›Paper›PMID 34544850›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Extracellular matrix protein N-glycosylation mediates immune self-tolerance in

Nathan T Mortimer, Mary L Fischer, Ashley L Waring, Pooja Kr, Balint Z Kacsoh, Susanna E Brantley, Erin S Keebaugh, Joshua Hill, Chris Lark, Julia Martin and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Parasitoid wasp venoms degradeScience advances · 2025
    Article
  4. Article
  5. Article
  6. The Lifespan ofInsects · 2024
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Nathan T MortimerSchool of Biological Sciences, Illinois State University, Normal, IL 61790; ntmorti@ilstu.edu.ORCID 0000-0003-3787-9445
Mary L FischerSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Ashley L WaringSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Pooja KrSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Balint Z KacsohEpigenetics Institute, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-9171-0611
Susanna E BrantleyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2420-1275
Erin S KeebaughDepartment of Biology, Emory University, Atlanta, GA 30322.
Joshua HillSchool of Biological Sciences, Illinois State University, Normal, IL 61790.ORCID 0000-0001-8383-3830
Chris LarkSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Julia MartinSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Pravleen BainsSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Jonathan LeeSchool of Biological Sciences, Illinois State University, Normal, IL 61790.
Alysia D Vrailas-MortimerSchool of Biological Sciences, Illinois State University, Normal, IL 61790.ORCID 0000-0001-5927-096X
Todd A SchlenkeDepartment of Entomology, University of Arizona, Tucson, AZ 85719.ORCID 0000-0003-3091-3057
Illinois State University · USEmory University · USStanford University · USUniversity of Arizona · USUniversity of Pennsylvania · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
A Model System For Host-Pathogen Interactions: Drosophila And Its Parasitic WaspsR01AI081879 · NIAID · UNIVERSITY OF ARIZONA · PI SCHLENKE, TODD ALEXANDER · 2009 to 2017
$2.8M
Regulation of Host Signaling by Parasitoid Venom ProteinsR35GM133760 · NIGMS · OREGON STATE UNIVERSITY · PI MORTIMER, NATHAN TERRY · 2019 to 2023
$1.2M
Characterizing Tissue Specific Regulation of Mutant Lamin Protein DegradationR15AG074113 · NIA · ILLINOIS STATE UNIVERSITY · PI HAMMOND, THOMAS MICHAEL · 2021 to 2021
$443k
The Role of p38K and protein homeostasis in Limb-Girdle Muscular DystrophiesR15AR070505 · NIAMS · ILLINOIS STATE UNIVERSITY · PI VRAILAS-MORTIMER, ALYSIA DANIELLE · 2016 to 2016
$435k
A Novel Drosophila Model to Understand the Role of Innate Immunity in Alzheimer's DiseaseR03AG063314 · NIA · ILLINOIS STATE UNIVERSITY · PI MORTIMER, NATHAN TERRY · 2019 to 2020
$293k
NIAID NIH HHS R01 AI081879NIAMS NIH HHS R15 AR070505NIA NIH HHS R03 AG063314NIA NIH HHS R15 AG074113NIGMS NIH HHS R35 GM133760NIH HHS P40 OD018537
6 · The paper itself

Abstract

In order to respond to infection, hosts must distinguish pathogens from their own tissues. This allows for the precise targeting of immune responses against pathogens and also ensures self-tolerance, the ability of the host to protect self tissues from immune damage. One way to maintain self-tolerance is to evolve a self signal and suppress any immune response directed at tissues that carry this signal. Here, we characterize the

Indexed as

MutationSelf ToleranceAnimalsDrosophila melanogasterDrosophila ProteinsExtracellular Matrix ProteinsGlycosylationHemocytesImmune ToleranceJanus KinasesDrosophila ProteinsExtracellular Matrix ProteinsJanus Kinasesautoimmunityinnate immunityprotein N-glycosylationself-recognitionself-tolerance

Identifiers

PMID34544850
PMCPMC8488588
OpenAlexW3199283225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.