Evidence map›Paper›PMID 34544838›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

CNS Hypomyelination Disrupts Axonal Conduction and Behavior in Larval Zebrafish.

M E Madden, D Suminaite, E Ortiz, J J Early, S Koudelka, M R Livesey, I H Bianco, M Granato, D A Lyons

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  6. Review
  7. Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
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  11. Towards Zebrafish Models of CNS Channelopathies.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

M E MaddenCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
D SuminaiteCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
E OrtizPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
J J EarlyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.ORCID 0000-0003-4313-6445
S KoudelkaCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
M R LiveseyCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
I H BiancoNeuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom.ORCID 0000-0002-3149-4862
M GranatoPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.
D A LyonsCentre for Discovery Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom david.lyons@ed.ac.uk.
MRC Centre for Regenerative Medicine · GBUniversity of Pennsylvania · USUniversity College London · GBUniversity of Edinburgh · GB

Funding

Molecular genetic mechanisms of spontaneous spinal cord regenerationR01NS097914 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato · 2017 to 2026
$3.3M
Cellular and molecular analysis of startle modulationR01NS118921 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2021 to 2025
$2.6M
Cellular and molecular analysis of startle modulationR01MH109498 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2016 to 2020
$2.4M
Genetic analysis of motor behavior regulationR01MH075691 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GRANATO, MICHAEL · 2005 to 2009
$1.5M
Cross-disciplinary training in computational approaches to the neuroscience of audition and communicationT32DC016903 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI Vijay Balasubramanian, Yale E Cohen · 2018 to 2026
$1.4M
Medical Research Council MR/P006272/1NIDCD NIH HHS T32 DC016903NIMH NIH HHS R01 MH075691NIMH NIH HHS R01 MH109498NINDS NIH HHS R01 NS097914NINDS NIH HHS R01 NS118921Wellcome TrustWellcome Trust 102836/Z/13/ZWellcome Trust 205042/Z/16/ZWellcome Trust 214244/Z/18/Z
6 · The paper itself

Abstract

Myelination is essential for central nervous system (CNS) formation, health and function. As a model organism, larval zebrafish have been extensively employed to investigate the molecular and cellular basis of CNS myelination, because of their genetic tractability and suitability for non-invasive live cell imaging. However, it has not been assessed to what extent CNS myelination affects neural circuit function in zebrafish larvae, prohibiting the integration of molecular and cellular analyses of myelination with concomitant network maturation. To test whether larval zebrafish might serve as a suitable platform with which to study the effects of CNS myelination and its dysregulation on circuit function, we generated zebrafish myelin regulatory factor (

Indexed as

Action PotentialsAcoustic StimulationAnimalsAxonsCentral Nervous SystemLarvaMembrane ProteinsMutationMyelin SheathReflex, StartleTranscription FactorsZebrafishZebrafish ProteinsMembrane Proteinsmyrf protein, zebrafishTranscription FactorsZebrafish Proteinscircuit functionelectrophysiologymyelinmyrfoligodendrocytezebrafish

Identifiers

PMID34544838
PMCPMC8570833
OpenAlexW3200539549

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.