Evidence map›Paper›PMID 34544834›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Somatostatin-Positive Interneurons Contribute to Seizures in

Eric R Wengert, Raquel M Miralles, Kyle C A Wedgwood, Pravin K Wagley, Samantha M Strohm, Payal S Panchal, Abrar Majidi Idrissi, Ian C Wenker, Jeremy A Thompson, Ronald P Gaykema and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  4. Nutrients · 2026
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  15. Heterozygous expression of abioRxiv : the preprint server for biology · 2024
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Eric R WengertDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Raquel M MirallesDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Kyle C A WedgwoodCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Living Systems Institute, Exeter, Devon EX4 4QD, United Kingdom.
Pravin K WagleyDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Samantha M StrohmDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Payal S PanchalDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Abrar Majidi IdrissiDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Ian C WenkerDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Jeremy A ThompsonDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Ronald P GaykemaDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908.
Manoj K PatelDepartment of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia, 22908 mkp5u@virginia.edu.
University of Virginia Health System · USUniversity of Exeter · GB

Funding

Role of CACHD1 in the development of temporal lobe epilepsy and absence epilepsyR01NS120702 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2021 to 2025
$2.0M
Pathogenesis of epilepsy in a SCN8A human mutation mouse modelR01NS103090 · NINDS · UNIVERSITY OF VIRGINIA · PI PATEL, MANOJ K · 2018 to 2022
$1.8M
Depolarization block of inhibitory neurons impacts neuronal function in epileptic encephalopathyF31NS115451 · NINDS · UNIVERSITY OF VIRGINIA · PI WENGERT, ERIC RYAN · 2019 to 2020
$61k
Medical Research Council MR/P01478X/1NINDS NIH HHS F31 NS115451NINDS NIH HHS R01 NS103090NINDS NIH HHS R01 NS120702
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Action PotentialsAnimalsBrain WavesInterneuronsMaleMiceMice, Inbred C57BLMutation, MissenseNAV1.6 Voltage-Gated Sodium ChannelSeizuresSomatostatinNAV1.6 Voltage-Gated Sodium ChannelScn8a protein, mouseSomatostatindepolarization blockepilepsyinterneuronion channelseizurevoltage-gated sodium channel

Identifiers

PMID34544834
PMCPMC8570835
OpenAlexW3200068605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.