ArticleJournal of immunology (Baltimore, Md. : 1950)2021
Elevated N-Linked Glycosylation of IgG V Regions in Myasthenia Gravis Disease Subtypes.
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Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
What it found
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- IgA autoantibodies demonstrate a novel mechanism of MuSK myasthenia gravis pathology.Brain : a journal of neurology · 2026Article
- Antibody glycosylation in neuroimmune diseases.Journal of translational medicine · 2025Review
- Fab N-Glycosylation in IgG: Implications in Physiological and Pathological Immune Regulation.Biomolecules · 2025Review
- Modulation of immunoglobulin G oligomerization by variable domain glycans: A mechanism to regulate complement activation.PNAS nexus · 2025Article
- Deep sequencing of BCR heavy chain repertoires in myalgic encephalomyelitis/chronic fatigue syndrome.Frontiers in immunology · 2025Article
- Glycosylation: mechanisms, biological functions and clinical implications.Signal transduction and targeted therapy · 2024Review
- Reverse Engineering of a Pathogenic Antibody Reveals the Molecular Mechanism of Vaccine-Induced Immune Thrombotic Thrombocytopenia.Journal of the American Chemical Society · 2023Article
- Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology.Acta neuropathologica · 2023Article
- Deciphering the Properties and Functions of Glycoproteins Using Quantitative Proteomics.Journal of proteome research · 2023Review
- Glycobiology of rheumatic diseases.Nature reviews. Rheumatology · 2023Review
- Disrupting N-Glycosylation Using Type I Mannosidase Inhibitors Alters B-Cell Receptor Signaling.ACS pharmacology & translational science · 2022Article
- Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy.Acta neuropathologica communications · 2022Article
- Novel pathophysiological insights in autoimmune myasthenia gravis.Current opinion in neurology · 2022Review
- Site-specific N-glycosylation characterization of micro monoclonal immunoglobulins based on EThcD-sceHCD-MS/MS.Frontiers in immunology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Caleigh Mandel-BrehmDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.ORCID 0000-0001-7764-6529
Miriam L FichtnerDepartment of Neurology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-0107-4103
Ruoyi JiangDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0002-8494-082X
Valerie J WintonProteomics Center of Excellence, Northwestern University, Evanston, IL.ORCID 0000-0001-9178-2252
Sara E VazquezDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.
Minh C PhamDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-0234-4790
Kenneth B HoehnDepartment of Pathology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-0411-4307
Neil L KelleherDepartment of Chemistry, Chemistry of Life Processes Institute, Proteomics Center of Excellence at Northwestern University, Evanston, IL.ORCID 0000-0002-8815-3372
Richard J NowakDepartment of Neurology, Yale University School of Medicine, New Haven, CT.
Steven H KleinsteinDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT.ORCID 0000-0003-4957-1544
Michael R WilsonWeill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA; and.ORCID 0000-0002-8705-5084
Joseph L DeRisiDepartment of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA.
Kevin C O'ConnorDepartment of Neurology, Yale University School of Medicine, New Haven, CT; kevin.oconnor@yale.edu.ORCID 0000-0002-7056-419X
Yale University · USUniversity of California, San Francisco · USNorthwestern University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MTR&D 7: Cell Specific ProteomicsP41GM108569 · NIGMS · NORTHWESTERN UNIVERSITY · PI KELLEHER, NEIL L · 2015 to 2024
$13.6MRare Disease Network for Myasthenia GravisU54NS115054 · NINDS · GEORGE WASHINGTON UNIVERSITY · PI HENRY J KAMINSKI · 2019 to 2026
$11.9MMedical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5MAutoimmune Encephalitis - Ataxia and Psychiatric Disease: Identifying and Characterizing Novel Antibody TargetsR01MH122471 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPH L. DERISI, SAMUEL JEREMY PLEASURE · 2020 to 2026
$4.7MMechanisms of autoimmunity in myasthenia gravisR01AI114780 · NIAID · YALE UNIVERSITY · PI Kevin C O'Connor · 2016 to 2026
$4.7MCOMPUTATIONAL TOOLS FOR THE ANALYSIS OF HIGH-THROUGHPUT IMMUNOGLOBULIN SEQUENCING EXPERIMENTSR01AI104739 · NIAID · YALE UNIVERSITY · PI KLEINSTEIN, STEVEN H. · 2014 to 2022
$3.6MNovel Approaches for Investigating the Pathology of Myasthenia Gravis AutoantibodiesR21AI142198 · NIAID · YALE UNIVERSITY · PI O'CONNOR, KEVIN C · 2019 to 2020
$395kMolecular understanding of self immunity in the brainK99NS117800 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANDEL-BREHM, CALEIGH · 2020 to 2021
$211kThe Role of RFX6 in Type 1 DiabetesF30DK123915 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAZQUEZ, SARA · 2019 to 2022
$183kIdentifying immunotherapy targets against thymus B cells in AChR myasthenia gravis (MG)F31AI154799 · NIAID · YALE UNIVERSITY · PI JIANG, RUOYI · 2020 to 2020
$30kNCATS NIH HHS UL1 TR001863NIAID NIH HHS F31 AI154799NIAID NIH HHS R01 AI104739NIAID NIH HHS R01 AI114780NIAID NIH HHS R21 AI142198NIDDK NIH HHS F30 DK123915NIGMS NIH HHS P41 GM108569NIGMS NIH HHS T32 GM007618NIGMS NIH HHS T32 GM141323NIMH NIH HHS R01 MH122471NINDS NIH HHS K99 NS117800NINDS NIH HHS U54 NS115054
Abstract
Elevated N-linked glycosylation of IgG V regions (IgG-V
Indexed as
AdultAgedAutoantibodiesB-LymphocytesFemaleGlycosylationHumansImmunoglobulin GImmunoglobulin Variable RegionMaleMiddle AgedMyasthenia GravisPhenotypeReceptors, Antigen, B-CellYoung AdultAutoantibodiesImmunoglobulin GImmunoglobulin Variable RegionReceptors, Antigen, B-Cell
Identifiers
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