Evidence map›Paper›PMID 34544759›Full record

ArticleeNeuro

CaMKII Modulates Diacylglycerol Lipase-α Activity in the Rat Nucleus Accumbens after Incubation of Cocaine Craving.

Conor H Murray, Andrew D Gaulden, Alex B Kawa, Mike Milovanovic, Aaron J Caccamise, Jonathan R Funke, Sachin Patel, Marina E Wolf

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Inactivation of NMDAR and CaMKII signaling within the prelimbic cortex blocks incubated cocaine- and sucrose-craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Changes in nucleus accumbens core translatome accompanying incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Conor H MurrayDepartment of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064-3095.
Andrew D GauldenDepartment of Psychiatry, Vanderbilt University, Nashville, Tennessee 37240.
Alex B KawaDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239-3098.
Mike MilovanovicDepartment of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064-3095.
Aaron J CaccamiseDepartment of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064-3095.
Jonathan R FunkeDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97239-3098.
Sachin PatelDepartment of Psychiatry, Vanderbilt University, Nashville, Tennessee 37240.
Marina E WolfDepartment of Neuroscience, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064-3095 wolfmar@ohsu.edu.ORCID 0000-0001-9129-3432
Oregon Health & Science University · USRosalind Franklin University of Medicine and Science · USVanderbilt University · US

Funding

BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
Reversal of AMPA receptor plasticity underlying incubation of cocaine cravingR01DA009621 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI Marina Elizabeth Wolf · 1996 to 2026
$8.5M
2-Arachidonoylglycerol signaling in anxiety, depression, and stress adaptationR01MH107435 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PATEL, SACHIN · 2016 to 2025
$5.0M
Dopamine and Glutamate Receptor InteractionsR37DA015835 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE &SCI · PI WOLF, MARINA ELIZABETH · 2003 to 2012
$2.8M
Synaptic mechanisms maintaining persistent cocaine craving.R01DA015835 · NIDA · ROSALIND FRANKLIN UNIV OF MEDICINE & SCI · PI WOLF, MARINA ELIZABETH · 2014 to 2018
$1.8M
OPHN1 translation and AMPA receptor plasticity during incubation of cravingF32DA050457 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KAWA, ALEXANDER BORG · 2020 to 2021
$131k
NIDA NIH HHS F32 DA050457NIDA NIH HHS R01 DA009621NIDA NIH HHS R01 DA015835NIDA NIH HHS R37 DA015835NIDA NIH HHS T32 DA007262NIMH NIH HHS R01 MH107435
6 · The paper itself

Abstract

Relapse is a major challenge to the treatment of substance use disorders. A progressive increase in cue-induced drug craving, termed incubation of craving, is observed after withdrawal from multiple drugs of abuse in humans and rodents. Incubation of cocaine craving involves the strengthening of excitatory synapses onto nucleus accumbens (NAc) medium spiny neurons via postsynaptic accumulation of high-conductance Ca

Indexed as

CocaineSubstance Withdrawal SyndromeAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2CravingLipoprotein LipaseNucleus AccumbensRatsRats, Sprague-DawleyCalcium-Calmodulin-Dependent Protein Kinase Type 2CocaineLipoprotein LipaseCaMKIIcocainediacylglycerol lipaseincubation of craving

Identifiers

PMID34544759
PMCPMC8503962
OpenAlexW3200589563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.